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  • EBME 422: Muscles, Biomechanics, and Control of Movement

    4.00 Credits
    Case Western Reserve University

    Quantitative and qualitative descriptions of the action of muscles in relation to human movement. Introduction to rigid body dynamics and dynamics of multi-link systems using Newtonian and Lagrangian approaches. Muscle models with application to control of multi-joint movement. Forward and inverse dynamics of multi-joint, muscle driven systems. Dissection, observation and recitation in the anatomy laboratory with supplemental lectures concentrating on kinesiology and muscle function. Recommended preparation: EMAE 181 or equivalent. Offered as EBME 422 and EMAE 402. Prereq: Graduate standing or Undergraduate with Junior or Senior standing and a cumulative GPA of 3.2 or above.
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  • EBME 425: Tissue Engineering and Regenerative Medicine

    3.00 Credits
    Case Western Reserve University

    This course will provide advanced coverage of tissue engineering with a focus on stem cell-based research and therapies. Course topics of note include stem cell biology and its role in development, modeling of stem cell function, controlling stem cell behavior by engineering materials and their microenvironment, stem cells' trophic character, and state-of-the-art stem cell implementation in tissue engineering and other therapeutic strategies. Offered as EBME 425 and PATH 435. Prereq: EBME 325 or equivalent or graduate standing.
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  • EBME 426: Nanomedicine

    3.00 Credits
    Case Western Reserve University

    Principles of the design and application of nanomedicine, including nanosized drug delivery systems, protein delivery systems, gene delivery systems and imaging probes. Methods for bioconjugation and surface modifications. Structure property relationships of nanosized biomaterials. In vivo and intracellular transport, pharmacokinetics, biodistribution, drug release kinetics, and biocompatibility of various nanosized therapeutics and diagnostics. Theranostics, image-guided drug delivery and therapy. Prereq: EBME 316 or EBME 416 or requisites not met permission
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  • EBME 427: Movement Biomechanics and Rehabilitation

    3.00 Credits
    Case Western Reserve University

    Introduction to the basic biomechanics of human movement and applications to the design and evaluation of artificial devices intended to restore or improve movement lost due to injury or disease. Measurement techniques in movement biomechanics, including motion analysis, electromyography, and gait analysis. Design and use of upper and lower limb prostheses. Principles of neuroprostheses with applications to paralyzed upper and lower extremities. Term paper required. Recommended preparation: Consent of instructor and graduate standing. Prereq: Graduate standing or Undergraduate with Junior or Senior standing and a cumulative GPA of 3.2 or above.
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  • EBME 431: Physics of Imaging

    3.00 Credits
    Case Western Reserve University

    Description of physical principles underlying the spin behavior in MR and Fourier imaging in multi-dimensions. Introduction of conventional, fast, and chemical-shift imaging techniques. Spin echo, gradient echo, and variable flip-angle methods. Projection reconstruction and sampling theorems. Bloch equations, T1 and T2 relaxation times, rf penetration, diffusion and perfusion. Flow imaging, MR angiography, and functional brain imaging. Sequence and coil design. Prerequisite may be waived with consent of instructor. Recommended preparation: PHYS 122 or PHYS 124 or EBME 410. Offered as EBME 431 and PHYS 431.
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  • EBME 440: Translational Research for Biomedical Engineers

    3.00 Credits
    Case Western Reserve University

    Translation of laboratory developments to improve biomedical and clinical research and patient care. Interdisciplinary and team communication. Evaluation of technology and research planning with clinical and engineering perspectives. Discussing clinical situations, shadowing clinicians, attending Grand Rounds and Morbidity-Mortality conferences. Validation study design. Regulatory/oversight organization. Protocol design and informed consent for Institutional Review Board (IRB) approval. NIH requirements for human subject research. Special project reports to produce IRB protocol or NIH-style proposal. Prereq: Graduate standing or Undergraduate with Junior or Senior standing and a cumulative GPA of 3.2 or above.
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  • EBME 447A: Rehabilitation for Scientists and Engineers

    0.00 Credits
    Case Western Reserve University

    Medical, psychological, and social issues influencing the rehabilitation of people with spinal cord injury, stroke, traumatic brain injury, and limb amputation. Epidemiology, anatomy, pathophysiology and natural history of these disorders, and the consequences of these conditions with respect to impairment, disability, handicap, and quality of life. Students will directly observe the care of patients in each of these diagnostic groups throughout the full continuum of care starting from the acute medical and surgical interventions to acute and subacute rehabilitation, outpatient medical and rehabilitation management and finally to community re-entry.
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  • EBME 447B: Rehabilitation for Scientists and Engineers

    3.00 Credits
    Case Western Reserve University

    Medical, psychological, and social issues influencing the rehabilitation of people with spinal cord injury, stroke, traumatic brain injury, and limb amputation. Epidemiology, anatomy, pathophysiology and natural history of these disorders, and the consequences of these conditions with respect to impairment, disability, handicap, and quality of life. Students will directly observe the care of patients in each of these diagnostic groups throughout the full continuum of care starting from the acute medical and surgical interventions to acute and subacute rehabilitation, outpatient medical and rehabilitation management and finally to community re-entry. Coreq: EBME 447A.
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  • EBME 451: Molecular and Cellular Physiology

    3.00 Credits
    Case Western Reserve University

    This course covers cellular and molecular basics for graduate students with little or no prior biology background. The emphasis of EBME 451 is on the molecular and cellular mechanisms underlying physiological processes. Structure-function relationship will be addressed throughout the course. The primary goal of the course is to develop understanding of the principles of the physiological processes at molecular and cellular level and to promote independent thinking and ability to solve unfamiliar problems. This course is no longer a core course of the Biomedical Engineering graduate curriculum but serves as a fundamentals course to prepare students for the graduate cellular and molecular physiology core. Prereq: Graduate standing.
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  • EBME 452: Tissue and Organ Systems Physiology

    3.00 Credits
    Case Western Reserve University

    Mechanisms of membrane and capillary-tissue transport, tissue mechanics, electrical propagation, signaling, control and regulation processes. Cardiac vascular, renal, respiratory, gastro-intestinal, neural, sensory, motor, musculoskeletal, and skeletal systems. Basic engineering analysis for quantitative understanding of physiological concepts. Prereq: Graduate standing or Undergraduate with Junior or Senior standing and a cumulative GPA of 3.2 or above.
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