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Course Criteria
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3.00 Credits
Thermodynamics and statistical thermodynamics and their application to chemical problems. Recommended preparation: Two semesters of undergraduate physical chemistry.
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3.00 Credits
Topics in physical chemistry, intended for entering graduate students, giving background tools appropriate for graduate research in areas of chemistry other than physical chemistry. Illustrations from the contemporary chemical research literature will be emphasized. Thermodynamics and statistical mechanics, quantum chemistry and computation, spectroscopy, and chemical kinetics and dynamics. Recommended preparation: One year of undergraduate physical chemistry.
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3.00 Credits
Chemistry of inorganic systems. Spectroscopy, magnetism, and stereochemistry of transition metal compounds. Recommended preparation: One semester of undergraduate inorganic chemistry and two semesters of undergraduate physical chemistry.
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3.00 Credits
Bonding, structure, and mechanistic aspects of organometallic chemistry and the relevance of organometallic species to chemical catalysis. Recommended preparation: One semester of undergraduate inorganic chemistry.
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3.00 Credits
Structure, bonding, and molecular orbital theory. Stereochemistry and conformational analysis. Reaction mechanisms. Aromaticity and aromatic substitution. Pericyclic reactions, orbital symmetry conservation, and free radical chemistry. Recommended preparation: Two semesters of undergraduate organic chemistry.
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3.00 Credits
Carbocations and carbanions. Nucleophilic and electrophilic aliphatic substitutions. Heterolytic addition and elimination reactions. Carbonyl reactions. Acyl transfer chemistry. Oxidations, reductions, and rearrangements. Prereq: CHEM 421 or consent of instructor.
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3.00 Credits
Structure determination of organic compounds using mass spectrometry and modern instrumental techniques such as infrared, ultraviolet, visible, and nuclear magnetic resonance spectroscopy. Recommended preparation: Two semesters of undergraduate organic chemistry. Offered as CHEM 325 and CHEM 425.
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3.00 Credits
A survey of biochemistry with a strong emphasis on the chemical logic underlying metabolic pathways and the evolution of biomolecules. Cellular architecture. Amino acids and protein structure, purification, analysis, and synthesis. DNA, RNA, the flow of genetic information, and molecular biological technology. Enzyme kinetics, catalytic, and regulatory strategies. Sugars, complex carbohydrates, and glycoproteins. Lipids and cell membranes. Glycolysis, gluconeogenesis, carbon fixation through the "dark reactions" of photosynthesis, aerobic catabolism through the citric acid cycle, and glycogen metabolism. Biosynthesis and degradation of fatty acids, amino acids, and proteins. Offered as CHEM 328 and CHEM 428.
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3.00 Credits
A survey of biochemical systems exploring their molecular circuitry and architecture. Protein structure and function. Lipids, cell membranes, channels and pumps. Redox processes and electron transport. Lipid and carbohydrate metabolism, its control, reciprocal regulation, and global integration. Nucleotide biosynthesis, DNA replication, recombination, and repair. RNA synthesis, splicing, and translation: protein synthesis and the control of gene expression. Sensory and immune systems. Molecular motors. Recommended preparation: Two semesters of undergraduate organic chemistry and one semester of undergraduate physical chemistry. Offered as CHEM 329 and CHEM 429.
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1.00 - 6.00 Credits
The course is designed for graduate students who will be focusing on one or more methods of structural biology in their thesis project. This course is divided into 3-6 sections (depending on demand). The topics offered will include X-ray crystallography, nuclear magnetic resonance spectroscopy, optical spectroscopy, mass spectrometry, cryo-electron microscopy, and computational and design methods. Students can select one or more modules. Modules will be scheduled so that students can take all the offered modules in one semester. Each section is given in 5 weeks and is worth 1 credit. Each section covers one area of structural biology at an advanced level such that the student is prepared for graduate level research in that topic. Offered as BIOC 430, CHEM 430, PHOL 430, and PHRM 430.
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