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Course Criteria
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3.00 Credits
This discussion-based course will introduce students to the exciting field of stem cell research. Students will first analyze basic concepts of stem cell biology, including stem cell niche, cell quiescence, asymmetric cell division, cell proliferation and differentiation, and signaling pathways involved in these processes. This first part of the course will focus on invertebrate genetic models for the study of stem cells. In the second part of the course, students will search for primary research papers on vertebrate and human stem cells, and application of stem cell research in regenerative medicine and cancer. Finally, students will have the opportunity to discuss about ethical controversies in the field. Students will rotate in weekly presentations, and will write two papers during the semester. Students will improve skills on searching and reading primary research papers, gain presentation skills, and further their knowledge in related subjects in the fields of cell biology, genetics and developmental biology. This course may be used as a cell/molecular subject area elective for the B.A. and B.S. Biology degrees. Offered as BIOL 324 and BIOL 424. Prereq: BIOL 325 or BIOL 326 or BIOL 362.
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3.00 Credits
This course will emphasize an understanding of the structure and function of eukaryotic cells from a molecular viewpoint. We will explore cell activities by answering the questions what do cells do and how do they do it. The answers to these questions will be developed using experimental evidence from the literature and explanations from the text. An important part of this course will be appreciation of the experimental evidence which supports our current understanding of cell function. To achieve this aim, students will read papers from the primary literature to supplement the text. Topics will include cell structure, protein structure and function, internal organization of the eukaryotic cell, membrane structure and function, protein sorting, organelle biogenesis, and cytoskeleton structure and function. The course will also cover the life cycles of cells, their interactions and finally use the immune response as a model of cell behavior. Prereq: BIOL 215 or BIOL 250.
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3.00 Credits
Transmission genetics, nature of mutation, microbial genetics, somatic cell genetics, recombinant DNA techniques and their application to genetics, human genome mapping, plant breeding, transgenic plants and animals, uniparental inheritance, evolution, and quantitative genetics. Offered as BIOL 326 and BIOL 426. Prereq: BIOL 214 or BIOL 250.
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3.00 Credits
The development of molecular tools has impacted agriculture as much as human health. The application of new techniques to improve food crops, including the development of genetically modified crops, has also become controversial. This course covers the nature of the plant genome and the role of sequenced-based methods in the identification of the genes. The application of the whole suite of modern molecular tools to understand plant growth and development, with specific examples related agronomically important responses to biotic and abiotic stresses, is included. The impact of the enormous amounts of data generated by these methods and their storage and analysis (bioinformatics) is also considered. Finally, the impact on both the developed and developing world of the generation and release of genetically modified food crops will be covered. Recommended preparation: BIOL 326. Offered as BIOL 328 and BIOL 428.
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3.00 Credits
Introduces basic chemical properties of proteins and discusses the physical forces that determine protein structure. Topics include: the elucidation of protein structure by NMR and by X-ray crystallographic methods; the acquisition of protein structures from data bases; and simple modeling experiments based on protein structures. Offered as BIOC 334, BIOL 334, BIOC 434, and BIOL 434.
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3.00 Credits
Physical, chemical, and biological dynamics of lake ecosystems. Factors governing the distribution, abundance, and diversity of freshwater organisms. Prereq: BIOL 214 or BIOL 251.
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3.00 Credits
Biology of fishes. Students will first develop fundamental understanding of the evolutionary history and systematics of fishes to provide a context within which they can address diverse aspects of biology including anatomy, physiology (e.g., in species that change sex; osmoregulation in freshwater vs. saltwater), and behavior (e.g. visual, auditory, chemical, electric communication; social structures). Finally, this knowledge will be used to explore the biodiversity of fishes around the world, with emphasis on Ohio species, by examining preserved specimens in class and making two local field trips to (1) observe captive living specimens, and (2) to observe, capture, and identify wild fishes in their natural habitats. The course will conclude with an analysis of the current global fisheries crisis that has resulted from human activities. Fishes will be used to address broad topics in ecology and evolutionary biology that transcend the pure study of ichthyology. Recommended preparation for BIOL 438: BIOL 216. Offered as BIOL 338 and BIOL 438. Prereq: BIOL 216 or BIOL 251.
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2.00 Credits
The physical, chemical, and biological limnology of freshwater ecosystems will be investigated. Emphasis will be on identification of the organisms inhabiting these systems and their ecological interactions with each other. This course will combine both field and laboratory analysis to characterize and compare the major components of these ponds. Students will have the opportunity to design and conduct individual projects. Prereq or Coreq: BIOL 336.
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3.00 Credits
This course will provide functional correlates to the students' previous knowledge of human anatomy. Building upon the basic principles covered in BIOL 216 and 346, the physiology of organs and organ systems of humans, including the musculoskeletal, nervous, cardiovascular, lymphatic, immune, respiratory, digestive, excretory, reproductive, and endocrine systems, will be studied at an advanced level. The contribution of each system to homeostasis will be emphasized. Prereq: BIOL 346 and BIOL 215 and BIOL 216 or BIOL 346 and BIOL 250 and BIOL 251
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3.00 Credits
This course will introduce students to classical and current parasitology. Students will discuss basic principles of parasitology, parasite life cycles, host-parasite interaction, therapeutic and control programs, epidemiology, and ecological and societal considerations. The course will explore diverse classes of parasitic organisms with emphasis on protozoan and helminthic diseases and the parasites' molecular biology. Group discussion and selected reading will facilitate further integrative learning and appreciation for parasite biology. This course counts as an elective in the cell/molecular biology subject area for the Biology BA and BS degrees. Offered as BIOL 342 and BIOL 442. Prereq: BIOL 214, 215, 216 and 326.
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