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Course Criteria
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4.00 Credits
No course description available.
Prerequisite:
Prereq: 9.01, 7.03, 7.05, or permission of instructor
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3.00 Credits
Evolution of behavior, the driver of nervous system evolution, is reviewed emphasizing concepts developed in ethology and sociobiology. Examines foraging and feeding, defensive and aggressive behavior, courtship and reproduction, migration and navigation, and various social activities and communication. Students consider the contributions of inherited patterns and cognitive abilities as well as the roles of various types of plasticity. Both field and laboratory studies are reviewed; human behavior is considered in the context of primate studies.
Prerequisite:
Prereq: 9.00 or permission of instructor
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3.00 Credits
Analyzes in detail developing topics in neurochemistry and neuropharmacology; focus varies by term. Students must be familiar with amino acid neurotransmitters, the loci, syntheses, modes of inactivation, receptors, and physiologic actions of the main monoamine. Open to juniors and seniors with permission of instructor.
Prerequisite:
Prereq: 9.150 or permission of instructor
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3.00 Credits
Introduction to normal and abnormal human brain functioning, including the cellular basis of activity-dependent development, critical periods, and plasticity of the brain through learning; neurotransmitters and emotional disorders; fMRI studies of vision, language, dyslexia, motor function, pain, placebo effects, and emotional states. Implications for education, prevention of dementia and dyslexia. Limited to 25.
Prerequisite:
Prereq: None
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3.00 Credits
Topics examined include regional functional anatomy of the CNS through imaging and stroke; degenerative diseases such as Parkinson's and Alzheimer's; immunological disorders such as multiple sclerosis and paraneoplastic syndromes; epilepsy; and gliomas. Emphasis on diseases for which a molecular mechanism is understood. Clinical and pathological findings, differential diagnosis, genetics, pathophysiology, and treatment are discussed for individual diseases. Limited to 25.
Prerequisite:
Prereq: 9.01
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3.00 Credits
Presents signal processing and statistical methods used to study neural systems and analyze neurophysiological data. Topics include state-space modeling formulated using the Bayesian Chapman-Kolmogorov system, theory of point processes, EM algorithm, Bayesian and sequential Monte Carlo methods. Applications include dynamic analyses of neural encoding, neural spike train decoding, studies of neural receptive field plasticity, algorithms for neural prosthetic control, EEG and MEG source localization. Students should know introductory probability theory and statistics. Alternate years.
Prerequisite:
Prereq: None
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3.00 Credits
Neural structures and mechanisms mediating the detection, localization, and recognition of sounds. Discussion of how acoustic signals are coded by auditory neurons, the impact of these codes on behavorial performance, and the circuitry and cellular mechanisms underlying signal transformations. Topics include temporal coding, neural maps and feature detectors, learning and plasticity, and feedback control. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, cochlear implants, and auditory scene analysis.
Prerequisite:
Prereq: Permission of instructor
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3.00 Credits
Mathematical introduction to the biophysics and circuits underlying neural computation. Topics include neuronal excitability, dendrites and cable theory, models of synaptic transmission, single-neuron dynamics, oscillators and sequence generation, and computation and dynamics in simple neuronal networks. Concepts applied to simple computing circuits in the behaving animal.
Prerequisite:
Prereq: 18.03, Physics II (GIR); or permission of instructor
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3.00 Credits
Examination of the role of neural plasticity during learning and memory of invertebrates and mammals. Detailed critical analysis of the current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Student-directed presentations and discussions of original papers supplemented by introductory lectures. Juniors and seniors require instructor's permission.
Prerequisite:
Prereq: Permission of instructor
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4.00 Credits
Surveys the mechanisms supporting plasticity in neurons, focusing on how it contributes to learning in several systems. Examines cellular forms of associative plasticity, including long-term potentiation and depression, metaplasticity, homeostatic plasticity, and depotentiation. Relates these phenomena to associative memory in animal systems and humans. Completion of 9.09 recommended.
Prerequisite:
Prereq: 9.01
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