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Course Criteria
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3.00 Credits
A survey of statistical methods for neuroscience research. Core topics include introductions to the theory of point processes, the generalized linear model, Monte Carlo methods, Bayesian methods, multivariate methods, time-series analysis, spectral analysis and state-space modeling. Emphasis on developing a firm conceptual understanding of the statistical paradigm and statistical methods primarily through analyses of actual experimental data.
Prerequisite:
Prereq: 9.07 or permission of instructor
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4.00 Credits
Introduction to the structure and function of the nervous system. Emphasizes the cellular properties of neurons and other excitable cells. Includes the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, integration of information in simple systems, and detection and information coding during sensory transduction.
Prerequisite:
Prereq: 7.05
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3.00 Credits
Explores the cognitive and neural processes that support attention, vision, language, motor control, navigation, and memory. Introduces basic neuroanatomy, functional imaging techniques, and behavioral measures of cognition. Discusses methods by which inferences about the brain bases of cognition are made. Considers evidence from human and animal models. Students prepare presentations summarizing journal articles.
Prerequisite:
Prereq: 9.01
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2.00 Credits
Experimental techniques in cellular and molecular neurobiology. Designed for students without previous experience in techniques of cellular and molecular biology. Experimental approaches include tissue culture of neuronal cell lines, dissection and culture of brain cells, DNA manipulation, synaptic protein analysis, immunocytochemistry, and fluorescent microscopy. One lab session plus one paper review session per week. Instruction and practice in written communication provided. Enrollment limited.
Prerequisite:
Prereq: 9.01, Biology (GIR)
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3.00 Credits
Outline of mammalian functional neuroanatomy, aided by studies of comparative neuroanatomy and evolution, and of brain development. Topics include early steps to a central nervous system, basic patterns of brain and spinal cord connections, regional development and differentiation, regeneration, motor and sensory pathways and structures, systems underlying motivations, innate action patterns, formation of habits, and various cognitive functions. Lab techniques reviewed. Optional brain dissections.
Prerequisite:
Prereq: 9.01
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4.00 Credits
No course description available.
Prerequisite:
Prereq: 9.01, 7.05, or permission of instructor
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4.00 Credits
Considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. Focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. Considers the involvement of particular neurotransmitters in human diseases.
Prerequisite:
Prereq: 9.011 or permission of instructor
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3.00 Credits
Surveys the mechanisms of neuronal communication. Covers ion channels in excitable membrane, single cell computation, synaptic transmission, and synaptic plasticity. Correlates the properties of ion channels and synaptic transmission with their physiological function. Discusses the organizational principles for the formation of functional neural networks at synaptic and cellular levels. Involves discussion of primary literature. Juniors and seniors require instructor's permission.
Prerequisite:
Prereq: 9.011 or permission of instructor
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3.00 Credits
Background in the theory and application of noninvasive imaging methods in biology and medicine, with emphasis on neuroimaging. Focuses on the modalities most frequently used in scientific research (x-ray CT, PET/SPECT, MRI, and optical imaging), and includes discussion of molecular imaging approaches used in conjunction with these scanning methods. Lectures are supplemented by in-class discussions of problems in research and demonstrations of imaging systems.
Prerequisite:
Prereq: 18.03, 8.03, or permission of instructor
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4.00 Credits
Considers molecular control of neural specification, formation of neuronal connections, construction of neural systems, and the contributions of experience to shaping brain structure and function. Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior. In addition to final exam, analysis and presentation of research papers required for final grade. Students taking graduate version complete additional assignments.
Prerequisite:
Prereq: 9.011 or permission of instructor
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