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  • 10 548J: Tumor Pathophysiology and Transport Phenomena: A Systems Biology Approach

    2.00 Credits
    Massachusetts Institute of Technology

    Tumor pathophysiology plays a central role in the growth, invasion, metastasis and treatment of solid tumors. Principles of transport phenomena are applied to develop a systems level, quantitative understanding of angiogenesis, blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, and treatment response. Prerequisite:    Prereq: 18.03; 10.301
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  • 10 55: Colloid and Surfactant Science

    3.00 Credits
    Massachusetts Institute of Technology

    Introduces fundamental and applied aspects of colloidal dispersions, where the typical particle size is less than a micrometer. Discusses the characterization and unique behavior of colloidal dispersions, including their large surface-to-volume ratio, tendency to sediment in gravitational and centrifugal fields, diffusion characteristics, and ability to generate osmotic pressure and establish Donnan equilibrium. Covers the fundamentals of attractive van der Waals forces and repulsive electrostatic forces. Presents an in-depth discussion of electrostatic and polymer-induced colloid stabilization, including the DLVO theory of colloid stability. Presents an introductory discussion of surfactant physical chemistry. Prerequisite:    Prereq: Permission of instructor
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  • 10 551: Systems Engineering

    3.00 Credits
    Massachusetts Institute of Technology

    Introduction to the elements of systems engineering. Special attention devoted to those tools that help students structure and solve complex problems. Illustrative examples drawn from a broad variety of chemical engineering topics, including product development and design, process development and design, experimental and theoretical analysis of physico-chemical process, analysis of process operations. Prerequisite:    Prereq: 10.213, 10.302, 10.37
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  • 10 552: Advanced Systems Engineering

    3.00 Credits
    Massachusetts Institute of Technology

    Covers modern methods for dynamical systems analysis, state estimation, controller design, and related topics. Uses example applications to demonstrate Lyapunov and linear matrix inequality-based methods that explicitly address actuator constraints, nonlinearities, and model uncertainties. Limited to 30. Prerequisite:    Prereq: None
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  • 10 555J: Bioinformatics: Principles, Methods and Applications

    3.00 Credits
    Massachusetts Institute of Technology

    Introduction to bioinformatics, the collection of principles and computational methods used to upgrade the information content of biological data generated by genome sequencing, proteomics, and cell-wide physiological measurements of gene expression and metabolic fluxes. Fundamentals from systems theory presented to define modeling philosophies and simulation methodologies for the integration of genomic and physiological data in the analysis of complex biological processes. Various computational methods address a broad spectrum of problems in functional genomics and cell physiology. Application of bioinformatics to metabolic engineering, drug design, and biotechnology also discussed. Prerequisite:    Prereq: Permission of instructor
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  • 10 557: Mixed-integer and Nonconvex Optimization

    3.00 Credits
    Massachusetts Institute of Technology

    Presents the theory and practice of deterministic algorithms for locating the global solution of NP-hard optimization problems. Recurring themes and methods are convex relaxations, branch-and-bound, cutting planes, outer approximation and primal-relaxed dual approaches. Emphasis is placed on the connections between methods. These methods will be applied and illustrated in the development of algorithms for mixed-integer linear programs, mixed-integer convex programs, nonconvex programs, mixed-integer nonconvex programs, and programs with ordinary differential equations embedded. The broad range of engineering applications for these optimization formulations will also be emphasized. Students will be assessed on homework and a term project for which examples from own research are encouraged. Prerequisite:    Prereq: 10.34 or 15.053
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  • 10 56: Advanced Topics in Surfactant Science

    3.00 Credits
    Massachusetts Institute of Technology

    Introduces fundamental advances and practical aspects of surfactant self-assembly in aqueous media. In-depth discussion of surfactant micellization, including statistical-thermodynamics of micellar solutions, models of micellar growth, molecular models for the free energy of micellization, and geometric packing theories. Presents an introductory examination of mixed micelle and vesicle formation, polymer-surfactant complexation, biomolecule-surfactant interactions, and micellar-assisted solubilization. Discusses molecular dynamics simulations of self-assembling systems. Covers recent advances in surfactant-induced dispersion and stabilization of colloidal particles (e.g., carbon nanotubes and graphene) in aqueous media. Examines surfactant applications in consumer products, environmental and biological separations, enhanced oil recovery using surfactant flooding, mitigation of skin irritation induced by surfactant-containing cosmetic products, and enhanced transdermal drug delivery using ultrasound and surfactants. Prerequisite:    Prereq: Permission of instructor
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  • 10 560: Structure and Properties of Polymers

    3.00 Credits
    Massachusetts Institute of Technology

    Review of polymer molecular structure and bulk morphology; survey of molecular and morphological influence on bulk physical properties including non-Newtonian flow, macromolecular diffusion, gas transport in polymers, electrical and optical properties, solid-state deformation, and toughness. Case studies for product design. Prerequisite:    Prereq: 10.213 or permission of instructor
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  • 10 568: Physical Chemistry of Polymers

    3.00 Credits
    Massachusetts Institute of Technology

    Chain macromolecules as random coils (unperturbed, expanded) and as other shapes. Statistical thermodynamics of interpenetrating random coiling polymers in solution with application to phase separations, swelling of networks, depression of melting point. The isolated chain molecule in dilute solutions analyzed for mass or size by static methods (osmometry, light scattering, neutron scattering) and by dynamic methods (intrinsic viscosity, size exclusion chromatography, sedimentation). Introduction to chain dynamics and to rubber elasticity. Prerequisite:    Prereq: 5.60, 10.213, or 10.40
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  • 10 569: Synthesis of Polymers

    3.00 Credits
    Massachusetts Institute of Technology

    Studies synthesis of polymeric materials, emphasizing interrelationships of chemical pathways, process conditions, and microarchitecture of molecules produced. Chemical pathways include traditional approaches such as anionic, radical condensation, and ring-opening polymerizations. New techniques, including stable free radicals and atom transfer free radicals, new catalytic approaches to well-defined architectures, and polymer functionalization in bulk and at surfaces. Process conditions include bulk, solution, emulsion, suspension, gas phase, and batch vs continuous fluidized bed. Microarchitecture includes tacticity, molecular-weight distribution, sequence distributions in copolymers, errors in chains such as branches, head-to-head addition, and peroxide incorporation. Prerequisite:    Prereq: 5.12
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