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Course Criteria
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3.00 Credits
Presents engineering principles and unit operations involved in the manufacture of small molecules pharmaceuticals, from the isolation of purified active pharmaceutical ingredients (API) to the final production of drug product. Regulatory issues include quality by design and process analytical technologies of unit operations, such as crystallization, filtration, drying, milling, blending, granulation, tableting and coating. Also covers principles of formulation for solid dosage forms and parenteral drugs. Students taking graduate version complete additional assignments. Limited to 50.
Prerequisite:
Prereq: 10.213
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3.00 Credits
Introduces principles and mathematical models of electrochemical energy conversion and storage. Studies equivalent circuits, thermodynamics, reaction kinetics, transport phenomena, electrostatics, porous media, and phase transformations. Includes applications to batteries, fuel cells, supercapacitors, and electrokinetics. Students taking graduate version complete additional assignments.
Prerequisite:
Prereq: 10.302 or permission of instructor
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3.00 Credits
Introduces fundamental and applied aspects of interfacial systems. Theory of capillarity. Experimental determination of surface and interfacial tensions. Thermodynamics of interfaces. The Gibbs adsorption equation. Charged interfaces. Surfactant adsorption at interfaces. Insoluble monolayers. Curvature effects on the equilibrium state of fluids. Nucleation and growth. Fundamentals of wetting and contact angle. Adhesion, cohesion, and spreading. Wetting of textured surfaces. Super-hydrophilic and super-hydrophobic surfaces. Self-cleaning surfaces.
Prerequisite:
Prereq: 10.213 or introductory subject in thermodynamics or physical chemistry
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4.00 Credits
Covers biological and bioengineering principles underlying the development and therapeutic use of recombinant proteins and stem cells; glycoengineering of recombinant proteins; normal and pathological signaling by growth factors and their receptors; receptor trafficking; monoclonal antibodies as therapeutics; protein pharmacology and delivery; stem cell-derived tissues as therapeutics; RNA therapeutics; combinatorial protein engineering; and new antitumor drugs.
Prerequisite:
Prereq: 2.005, 3.012, 5.60, 20.110, or 20.111; 7.06; or permission of instructor
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3.00 Credits
Provides an introduction to pharmaceutics and conventional oral, injected, transdermal and inhaled drug delivery systems. Includes studies of drug delivery devices and systems, e.g., stents, pumps, depo systems, responsive drug delivery systems, and biological/cell based therapies. Covers nano- and micro drug delivery systems, including polymer-drug conjugates, modified proteins, liposomes and polymer nanoparticles, viral and non-viral genetic therapy, and microencapsulated vaccines. Discusses reviews and current technology. Students taking graduate version complete additional assignments. Limited to 40.
Prerequisite:
Prereq: 7.05 or permission of instructor
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3.00 Credits
Introduction to dynamic processes and the engineering tasks of process operations and control. Subject covers modeling the static and dynamic behavior of processes; control strategies; design of feedback, feedforward, and other control structures; model-based control; applications to process equipment.
Prerequisite:
Prereq: 10.302, 18.03
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2.00 Credits
Experiments broadly aimed at acquainting students with the range of properties of polymers, methods of synthesis, and physical chemistry. Examples: solution polymerization of acrylamide, bead polymerization of divinylbenzene, interfacial polymerization of nylon 6,10. Evaluation of networks by tensile and swelling experiments. Rheology of polymer solutions and suspensions. Physical properties of natural and silicone rubber. Preference to Course 10 seniors and juniors.
Prerequisite:
Prereq: 5.12, 5.310
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3.00 Credits
No course description available.
Prerequisite:
Prereq: 10.37
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3.00 Credits
Presents and solves chemical engineering problems in an industrial context, with applications varying by term. Emphasis on the integration of fundamental concepts with approaches of process design. Emphasis on problems that demand synthesis, economic analysis, and process design.
Prerequisite:
Prereq: 10.490
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2.00 Credits
No course description available.
Prerequisite:
Prereq: 10.301 and permission of instructor
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