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Course Criteria
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3.00 Credits
Molecular diffusion, diffusion-reaction, conduction, convection in biological systems; fields in heterogeneous media; electrical double layers; Maxwell stress tensor, electrical forces in physiological systems. Fluid and solid continua: equations of motion useful for porous, hydrated biological tissues. Case studies of membrane transport, electrode interfaces, electrical, mechanical, and chemical transduction in tissues, convective-diffusion/reaction, electrophoretic, electroosmotic flows in tissues/MEMs, and ECG. Electromechanical and physicochemical interactions in cells and biomaterials; musculoskeletal, cardiovascular, and other biological and clinical examples.
Prerequisite:
Prereq: 6.013, 2.005, 10.302, or permission of instructor
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4.00 Credits
Conceptual and experimental approaches to analyzing complex biological networks and systems, from molecules to human populations, focusing on human pathophysiology and disease. Moving from single component analysis to pathways and networks, combines didactic lectures with in-depth analysis of current literature. Emphasizes the chemistry and biochemistry of underlying biological processes. Topics include linking genes/SNPs to disease, defining pathways, analysis of pathways in vivo, systems-level analysis, and applications of network biology. First half of term focuses on fundamental biological processes and tools/analyses needed by biological engineers, and the second half elaborates on these fundamentals by covering complex biological processes. Students acquire skills in the fundamentals of grant preparation using an NIH format and make an oral presentation.
Prerequisite:
Prereq: Permission of instructor
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3.00 Credits
Principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. Mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Tissue and organ regeneration. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.
Prerequisite:
Prereq: Chemistry (GIR), Biology (GIR), Physics I (GIR); or permission of instructor
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3.00 Credits
Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular design of new biological materials for nanotechnology, biocomputing and regenerative medicine. Graduate students are expected to complete additional coursework.
Prerequisite:
Prereq: 5.07 or 7.05; permission of instructor
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3.00 Credits
Students will read and discuss primary literature covering key areas of microbial research with emphasis on methods and approaches used to understand and manipulate microbes. Limited to students in the microbiology program.
Prerequisite:
Prereq: Permission of instructor or Coreq: 7.493
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4.00 Credits
Covers aspects of microbial genetic and genomic analyses, central dogma, horizontal gene transfer, and evolution.
Prerequisite:
Prereq: 7.03, 7.05, 7.28 or permission of instructor
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4.00 Credits
Fundamentals of tissue and organ response to injury are examined from a molecular and cellular perspective. Special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. Systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations.
Prerequisite:
Prereq: 20.420, 20.440; or permission of instructor
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3.00 Credits
Solution of clinical problems by use of implants and other medical devices. Systematic use of cell-matrix control volumes. The role of stress analysis in the design process. Anatomic fit: shape and size of implants. Selection of biomaterials. Instrumentation for surgical implantation procedures. Preclinical testing for safety and efficacy: risk/benefit ratio assessment. Evaluation of clinical performance: design of clinical trials. Project materials drawn from orthopedic devices, soft tissue implants, artificial organs, and dental implants.
Prerequisite:
Prereq: Chemistry (GIR), Biology (GIR), Physics I (GIR); or permission of instructor
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3.00 Credits
Covers principles underlying current and future technologies for brain analysis and engineering, for neurology, psychiatry, and neuroscience. Focuses on using biophysical, biochemical, and anatomical models to understand technology design constraints governing ability to observe and alter brain function. Topics include functional magnetic resonance imaging, electromagnetic recording/stimulation, neuropharmacology, optical cellular imaging, and gene/stem-cell therapy. Design projects by student teams. Limited to 28.
Prerequisite:
Prereq: 8.03, 6.003, 9.01; or permission of instructor
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2.00 Credits
Special seminar focusing on the challenges of envisioning, planning, and building start-ups that are commercializing innovations from neuroscience and the blossoming domain of neuroengineering. Topics include neuroimaging and diagnostics, psychophysiology, rehab feedback, affective computing, neurotherapeutics, surgical tools, neuropharmaceuticals, deep brain stimulation, prosthetics and neurobionics, artificial senses, nerve regeneration, and more. Each class is devoted to a specific topic area. The first hour covers the topic in survey form. The second hour is dedicated to a live case study of a specific organization. A broad spectrum of issues, from the deeply technical through market opportunity, is explored in each class.
Prerequisite:
Prereq: Permission of instructor
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