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Course Criteria
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4.00 Credits
Analysis of molecular and cellular processes across a hierarchy of scales, including genetic, molecular, cellular, and cell population levels. Topics include gene sequence analysis, molecular modeling, metabolic and gene regulation networks, signal transduction pathways and cell populations in tissues. Emphasis on experimental methods, quantitative analysis, and computational modeling.
Prerequisite:
Prereq: 20.110, 18.03, 6.00; Coreq: 5.07
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4.00 Credits
Introduction to electric fields, fluid flows, transport phenomena and their application to biological systems. Flux and continuity laws, Maxwell's equations, electro-quasistatics, electro-chemical-mechanical driving forces, conservation of mass and momentum, Navier-Stokes flows, and electrokinetics. Applications include biomolecular transport in tissues, electrophoresis, and microfluidics.
Prerequisite:
Prereq: 2.005, 6.021, 20.320 or permission of instructor
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3.00 Credits
Introduction to the interactions between cells and surfaces of biomaterials. Surface chemistry and physics of selected metals, polymers, and ceramics. Surface characterization methodology. Modification of biomaterials surfaces. Quantitative assays of cell behavior in culture. Biosensors and microarrays. Bulk properties of implants. Acute and chronic response to implanted biomaterials. Topics in biomimetics, drug delivery, and tissue engineering.
Prerequisite:
Prereq: Chemistry (GIR), Biology (GIR), 3.034, 3.012 or 3.046; or permission of instructor
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3.00 Credits
Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular design of new biological materials for nanotechnology, biocomputing and regenerative medicine. Graduate students are expected to complete additional coursework.
Prerequisite:
Prereq: 5.07 or 7.05; permission of instructor
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2.00 Credits
In-depth examination of instrumentation design, principles and techniques for studying biological systems, from single molecules to entire organisms. Lectures cover optics, advanced microscopy techniques, electronics for biological measurement, magnetic resonance imaging, computed tomography, MEMs, microfluidic devices, and limits of detection. Students select two lab exercises during the first half of the semester and complete a final design project in the second half. Lab emphasizes design process and skillful realization of a robust system.
Prerequisite:
Prereq: Biology (GIR), and 2.004 or 6.003; or 20.309; or permission of instructor
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3.00 Credits
Analysis of fundamental processes in tissue engineering with an emphasis on use of comparative animal models and in vitro tissue engineered models to understand human disease and develop therapies for human disease and for regenerating human tissues and organs. using representative examples of metabolic tissue (e.g., liver) and connective tissue (e.g., bone). Design principles and engineering approaches (e.g., use of synthetic materials) for controlling receptor-mediated processes such as cell migration, growth, and differentiation. Mass transfer limitations in design of devices for cell encapsulation and in scaffold-guided regeneration. Guided organization of multicellular structures. Current clinical prospects.
Prerequisite:
Prereq: 5.07 or 7.05; 7.03; 18.03; 20.110 or 5.60
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4.00 Credits
Covers biological and bioengineering principles underlying the development and therapeutic use of recombinant proteins and stem cells; glycoengineering of recombinant proteins; normal and pathological signaling by growth factors and their receptors; receptor trafficking; monoclonal antibodies as therapeutics; protein pharmacology and delivery; stem cell-derived tissues as therapeutics; RNA therapeutics; combinatorial protein engineering; and new antitumor drugs.
Prerequisite:
Prereq: 2.005, 3.012, 5.60, 20.110, or 20.111; 7.06; or permission of instructor
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3.00 Credits
Covers, at a molecular scale, the analysis and design of materials used in contact with biological systems, and biomimetic strategies aimed at creating new materials based on principles found in biology. Topics include molecular interaction between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces. Students taking graduate version complete additional assignments.
Prerequisite:
Prereq: 3.034, 20.110, or permission of instructor
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5.00 Credits
Integrated overview of the biophysics of cells from prokaryotes to neurons, with a focus on mass transport and electrical signal generation across cell membrane. First half of course focuses on mass transport through membranes: diffusion, osmosis, chemically mediated, and active transport. Second half focuses on electrical properties of cells: ion transport to action potentials in electrically excitable cells. Electrical properties interpreted via kinetic and molecular properties of single voltage-gated ion channels. Laboratory and computer exercises illustrate the concepts. Provides instruction in written and oral communication. Students taking graduate version complete different assignments. Preference to juniors and seniors.
Prerequisite:
Prereq: Physics II (GIR); 18.03; 2.005, 6.002, 6.003, 6.071, 10.301, 20.110, 20.111, or permission of instructor
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4.00 Credits
Application of the principles of energy and mass flow to major human organ systems. Mechanisms of regulation and homeostasis. Anatomical, physiological and pathophysiological features of the cardiovascular, respiratory and renal systems. Systems, features and devices that are most illuminated by the methods of physical sciences. Laboratory work includes some animal studies.
Prerequisite:
Prereq: Physics II (GIR), 18.03, or permission of instructor
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