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Course Criteria
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5.00 Credits
Provides a quantitative approach to understanding the physical and chemical laws that govern the behavior of biological macromolecules. Basic thermodynamics, state of a system, state variables. Work, heat, first, second, and third laws of thermodynamics. Entropy and its statistical basis, free energy representations, Legendre transforms, Maxwell relations, Gibbs function, Boltzmann distribution and partition functions. Equilibrium properties of macroscopic and microscopic systems; macromolecular structure and interactions in solution. Driving forces for molecular self-assembly. Binding, cooperativity, solvation, and titration of macromolecules. Applications of introductory quantum mechanics to spectroscopy.
Prerequisite:
Prereq: Calculus II (GIR), Chemistry (GIR), Physics I (GIR); Coreq: Physics II (GIR)
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1.00 Credits
Weekly one-hour seminars covering graduate student research and presentations by invited speakers.
Prerequisite:
Prereq: Open only to BE graduate students, or by permission of instructor
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4.00 Credits
Chemical and biological analysis of the metabolism and distribution of drugs and chemicals in animals and humans, and the mechanisms by which they cause therapeutic and toxic responses. Examines pharmacokinetics, metabolism, pharmacodynamics, toxicity and pharmacogenetics as foundations for drug development. Includes case studies and literature discussions of specific drugs, drug classes, and therapeutic targets.
Prerequisite:
Prereq: Permission of instructor
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1.00 Credits
Selected aspects of anatomy, histology, immuno-cytochemistry, in situ hybridization, physiology, and cell biology of mammalian organisms and their pathogens. Subject material integrated with principles of toxicology, in vivo genetic engineering, and molecular biology. A lab/demonstration period each week involves experiments in anatomy (in vivo), physiology, and microscopy to augment the lectures. Offered first half of spring term.
Prerequisite:
Prereq: Permission of instructor
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2.00 Credits
Focuses on the biochemistry and molecular mechanisms of DNA replication and DNA repair. Analyzes the chemistry of DNA damaging events, and continues with analysis of the mutagenic and toxic consequences of modifications to DNA structure. Also presents the contrasting perspective that normal DNA processing leads to mutations. Moves from analysis and discussion of key DNA repair pathways to connections between DNA repair and human diseases. Discussion of current literature and in-depth discussions of the chemistry and biochemistry of DNA metabolism form the foundation of the subject.
Prerequisite:
Prereq: 5.07, 7.05, permission of instructor
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3.00 Credits
Studies the logic and technology needed to discover genetic and environmental causes and accelerating factors for common human cancers. Includes an introduction to metakaryotic stem cell biology. Analyzes large, organized historical public health databases using quantitative carcinogenesis cascade computer models. Means to test hypotheses that certain genes carry mutations conferring risk for common cancers via genetic analyses in large human cohorts.
Prerequisite:
Prereq: Calculus II (GIR), 1.00
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0.00 - 6.00 Credits
Detailed discussion of selected topics of current interest. Classwork in various areas not covered by regular subjects.
Prerequisite:
Prereq: Permission of Instructor
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3.00 Credits
Introduces the basics of synthetic biology, including quantitative cellular network characterization and modeling. Considers the discovery and genetic factoring of useful cellular activities into reusable functions for design. Emphasizes the principles of biomolecular system design and diagnosis of designed systems. Illustrates cutting-edge applications in synthetic biology and enhances skills in analysis and design of synthetic biological applications. Students taking graduate version complete additional assignments.
Prerequisite:
Prereq: None
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3.00 Credits
Sensing and measurement aimed at quantitative molecular/cell/tissue analysis in terms of genetic, biochemical, and biophysical properties. Methods include light and fluorescence microscopies, electronic circuits, and electro-mechanical probes (atomic force microscopy, optical traps, MEMS devices). Application of statistics, probability, signal and noise analysis, and Fourier techniques to experimental data. Final design project emphasizes utilization of principles underlying biological instrumentation. Preference to juniors and seniors.
Prerequisite:
Prereq: Biology (GIR), Physics II (GIR), 6.00, 18.03; 2.001, 20.310, or 6.02; or permission of instructor; Coreq: 20.330
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4.00 Credits
Develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels.
Prerequisite:
Prereq: 2.370 or 2.772J; 18.03 or 3.016; Biology (GIR)
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