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Course Criteria
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0.00 - 6.00 Credits
Individual self-motivated study, research, or design project under faculty supervision. Departmental program requirement: minimum of 6 units. Instruction and practice in written communication provided.
Prerequisite:
Prereq: None
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0.00 - 6.00 Credits
No course description available.
Prerequisite:
Prereq: None
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0.00 - 6.00 Credits
Individual study, research, or laboratory investigations under faculty supervision, including individual participation in an ongoing research project. See projects listing in Undergraduate Office, 1-110, for guidance.
Prerequisite:
Prereq: None
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2.00 Credits
Integration of biological stem cell hypotheses and mathematical models of age-specific mortality. Introduces amitotic metakaryotic stem cells that drive organogenesis and wound healing. Discusses topics such as the role of metakaryotic mutator fetal/juvenile phenotype in generation of preneoplastic lesions and lethal tumors, and non-canonical metakaryotic genome organization, replication and segregation in human tissues, tumors and tumor-derived cell cultures. Studies the relationship to age-specific cancer and other disease rates observed in human populations.
Prerequisite:
Prereq: None
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3.00 Credits
Project-based introduction to the engineering of synthetic biological systems. Throughout the term, students develop projects that are responsive to real-world problems of their choosing, and whose solutions depend on biological technologies. Lectures, discussions, and studio exercises will introduce components and control of prokaryotic and eukaryotic behavior; DNA synthesis, standards, and abstraction in biological engineering; and issues of human practice, including biological safety, security, ethics, and ownership, sharing, and innovation. Preference to freshmen.
Prerequisite:
Prereq: None
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3.00 Credits
Explores the origins of human clonal diseases using cytologic, genetic and mathematical observations incorporated in computer cascade models. Provides an introduction to metakaryotic stem cell biology. Application to the analysis of age-specific disease mortality data for the US from 1900 to 2006. Includes basic population genetics of inherited risk factors and considers environmental changes coincident with historical shifts in disease risk. Students taking 20.215 do additional research and computer modeling.
Prerequisite:
Prereq: Calculus I (GIR)
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3.00 Credits
Considers potentially important risk factors for common cancers in the general environment and the workplace: air-, food- and water-borne chemicals; subclinical infections; and diet and lifestyle choices. Includes an analysis of the history of cancer mortality rates in predominantly European- and African-American cohorts. Examines metakaryotic cancer stem cells as targets for both pathogenic environmental risk factors and drugs that prevent the growth of or kill preneoplastic and/or neoplastic stem cells.
Prerequisite:
Prereq: Biology (GIR), Chemistry (GIR)
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3.00 Credits
Introductory microbiology from a systems perspective. Considers microbial diversity, population dynamics, and genomics. Emphasize the delicate balance between microbes and humans, and changes that result in the emergence of infectious diseases and antimicrobial resistance. Case study approach covers topics such as vaccines, toxins, biodefense, and infections including Legionnaire's disease, tuberculosis, Helicobacter pylori, and plague.
Prerequisite:
Prereq: Chemistry (GIR), Biology (GIR)
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2.00 Credits
Introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, data analysis, and scientific communication form the underpinnings of this subject. Examples of discovery-based experimental modules include: DNA Engineering in which students design, construct, and use genetic material; Parts Engineering, which emphasizes protein design and quantitative assessment of protein performance; Systems Engineering, in which students consider genome-wide consequences of genetic perturbations; and Biomaterials Engineering, in which students use biologically-encoded devices to design and build materials. Enrollment limited; priority to Course 20 majors.
Prerequisite:
Prereq: Biology (GIR), Chemistry (GIR), 6.00, 18.03; 20.110 or 20.111
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5.00 Credits
Equilibrium properties of macroscopic and microscopic systems. Basic thermodynamics: state of a system, state variables. Work, heat, first law of thermodynamics, thermochemistry. Second and third law of thermodynamics: entropy and its statistical basis, Gibbs function. Chemical equilibrium of reactions in gas and solution phase. Macromolecular structure and interactions in solution. Driving forces for molecular self-assembly. Binding cooperativity, solvation, titration of macromolecules.
Prerequisite:
Prereq: Calculus II (GIR), Chemistry (GIR)
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