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Course Criteria
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4.00 Credits
Application of the principles of energy and mass flow to major human organ systems. Mechanisms of regulation and homeostasis. Anatomical, physiological and pathophysiological features of the cardiovascular, respiratory and renal systems. Systems, features and devices that are most illuminated by the methods of physical sciences. Laboratory work includes some animal studies.
Prerequisite:
Prereq: Physics II (GIR), 18.03, or permission of instructor
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4.00 Credits
Introduction to electric fields, fluid flows, transport phenomena and their application to biological systems. Flux and continuity laws, Maxwell's equations, electro-quasistatics, electro-chemical-mechanical driving forces, conservation of mass and momentum, Navier-Stokes flows, and electrokinetics. Applications include biomolecular transport in tissues, electrophoresis, and microfluidics.
Prerequisite:
Prereq: 2.005, 6.021, 20.320 or permission of instructor
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5.00 Credits
Meets with undergraduate subject 6.021J. Requires the completion of more advanced home problems and/or an additional project.
Prerequisite:
Prereq: Physics II (GIR); 18.03; 2.005, 6.002, 6.003, 6.071, 10.301, 20.110, or permission of instructor
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3.00 Credits
Molecular diffusion, diffusion-reaction, conduction, convection in biological systems; fields in heterogeneous media; electrical double layers; Maxwell stress tensor, electrical forces in physiological systems. Fluid and solid continua: equations of motion useful for porous, hydrated biological tissues. Case studies of membrane transport, electrode interfaces, electrical, mechanical, and chemical transduction in tissues, convective-diffusion/reaction, electrophoretic, electroosmotic flows in tissues/MEMs, and ECG. Electromechanical and physicochemical interactions in cells and biomaterials; musculoskeletal, cardiovascular, and other biological and clinical examples.
Prerequisite:
Prereq: 6.013, 2.005, 10.302, or permission of instructor
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4.00 Credits
Meets with undergraduate subject 6.022J. Requires the completion of more advanced home problems and/or an additional project.
Prerequisite:
Prereq: 2.006 or 6.013; 6.021
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4.00 Credits
Develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels.
Prerequisite:
Prereq: 2.370 or 2.772J; 18.03 or 3.016; Biology (GIR)
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3.00 Credits
Develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels.
Prerequisite:
Prereq: Biology (GIR); 2.002, 2.006, 6.013, 10.301, or 10.302
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3.00 Credits
Principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. Mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Tissue and organ regeneration. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.
Prerequisite:
Prereq: Chemistry (GIR), Biology (GIR), Physics I (GIR); or permission of instructor
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3.00 Credits
Introduction to manufacturing processes and manufacturing systems including assembly, machining, injection molding, casting, thermoforming, and more. Emphasis on the physics and randomness and how they influence quality, rate, cost, and flexibility. Attention to the relationship between the process and the system, and the process and part design. Project (in small groups) requires fabrication (and some design) of a product using several different processes (as listed above).
Prerequisite:
Prereq: 2.001, 2.006, 2.008
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3.00 Credits
Introduction to the major dilemma that faces manufacturing and society for the 21st century: how to support economic development while protecting the environment. Subject addresses industrial ecology, materials flows, life-cycle analysis, thermodynamic analysis and exergy accounting, manufacturing process performance, product design analysis, design for the environment, recycling and ecological economics. Combines lectures and group discussions of journal articles and selected literature, often with opposing views. Graduate students complete term-long project with report required for graduate credit.
Prerequisite:
Prereq: 2.008 or permission of instructor
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