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Course Criteria
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4.00 Credits
This advanced laboratory course will apply experimental approaches and surgical techniques to illustrate critical developmental events during mouse embryogenesis. Particular emphasis will be placed on experiments covering the following topics: fertilization and pre-implantation embryology; reprogramming of adult somatic cells into embryonic stem cells; early organ development; and surgical manipulation of late stage mouse embryos in utero.
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4.00 Credits
This laboratory course will allow advanced undergraduate students to explore classical and modern experimental models of regeneration, and through experimentation, understand the important concepts and key challenges of the regenerative biology field. We will focus in particular on the regeneration of complex tissues and entire organ systems using both invertebrate and vertebrate models, including the planarian worm, the salamander, and the mouse.
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4.00 Credits
This practical laboratory course will investigate the fundamental biology of human embryonic stem cells and their remarkable capacity to differentiate into all cells of the body. The underlying developmental pathways that guide embryonic stem cell development into these differentiated cell types will be explored. A chemical biology approach will also be used to probe properties of normal and disease model cells derived from embryonic stem cells.
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4.00 Credits
Stem cells are the basis for tissue maintenance and repair, thus, are essential elements of normal organ and tissue physiology. Stem cells are also targets for disease processes and through transplantation are important therapeutic agents. This course will allow advanced undergraduates to explore how stem cells and tissue regeneration impact human disease pathogenesis and how stem cells might be exploited to advance new therapies for disease.
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4.00 Credits
Heart stem cell therapeutics is a paradigm for regenerative medicine. Multipotent "master" heart progenitors are revolutionizing our understanding of human cardiogenesis and its relationship to disease. Issues such as delivery, grafting, survival, rejection, scalability, tissue engineering, unwanted side effects, and imaging have all arisen when considering cell transplantation therapies. This course will examine the prospects and problems of heart stem cell therapeutics from multiple perspectives, e.g., scientific, medical, philanthropic, drug discovery/safety, governmental, ethical, and financial.
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4.00 Credits
One session each week is a lecture on current topics in immunology. At the second session, three papers are read from the current literature on that topic (including topics in hematopoietic stem cells, immune cell differentiation, autoimmunity, HIV, cancer, and transplantation), each presented by a student in 30-45 minutes. Course work: reading of papers, seminar presentations, and class participation.
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4.00 Credits
This course will discuss cellular and molecular mechanisms of regeneration and repair in the mammalian central nervous system (CNS). We will: compare and contrast aspects of neural development with adult neural plasticity; discuss limitations to neuronal regeneration in the mature mammalian CNS following degeneration or injury; examine CNS regeneration approaches directed at overcoming intrinsic limitations; and explore developmental controls and gene manipulation to promote neurogenesis, axonal regeneration, and directed differentiation in the diseased adult brain.
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4.00 Credits
This lecture and discussion course will explore the fundamental molecular and cellular mechanisms that govern organismal aging and contemporary strategies to delay or reverse this process.
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4.00 Credits
This course will introduce students to classic experiments in developmental biology. We will explore the historical background, experimental design, and results of a handful of experiments that have defined the field of developmental biology and changed our understanding of the discipline. Students will read primary literature and, in turn, present the conclusions in written and oral formats.
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4.00 Credits
Laboratory research in topics related to the Human Developmental and Regenerative Biology Concentration under the direction of, or approved by, members of the Department of Stem Cell and Regenerative Biology, Principal Faculty of the Harvard Stem Cell Institute, or others with permission. A paper must be submitted to the laboratory sponsor and to the HDRB Concentration Office for review by the Course Director and Head Tutors.
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