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Course Criteria
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4.00 Credits
This course is a collaboration between world-class chefs and Harvard professors. Each week, a chef will lecture about some aspect of gastronomy. This lecture will introduce and motivate a lecture about the science of soft materials by the Harvard professors. The course will cover the basic concepts in the science of soft materials, providing a solid understanding of their properties and behavior. All food is made of soft materials, and cooking relies on many of their fundamental properties. The course will also include laboratory work that uses concepts of cooking to understand and motivate experimental measurements on soft materials.
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4.00 Credits
What we perceive as "reality" is the best effort of our senses to interpret a deeper, largely invisible, reality that is unnervingly strange. This course will survey the world of very small things, objects with dimensions of nanometers and micrometers. The behaviors of these objects are often entirely counterintuitive; they can also be quite useful. Micro- and nanostructures are the basis both of fundamentally new science, and of ubiquitous technologies: quantum dots, computers, the biological nanomotors that power muscle, buckyballs, tools for examining single mammalian cells, lasers. The course will describe these objects and how they function; it will also touch on issues of commercialization, economics, public policy, and ethics that spring from the avalanche of discovery and invention in this area.
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4.00 Credits
This course will examine future climate change in the context of Earth history, and then consider various strategies for what might be done to deal with it. The likely impacts of continued greenhouse gas emissions will be explored, emphasizing the scientific uncertainties associated with various predictions, and how this can be understood in the context of risk. In the latter third of the class, the question of how to mitigate climate change will be discussed, including an examination of various options for advanced energy systems.
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4.00 Credits
This course considers the relationship between life and the planet on which it resides. It examines the scientific quest to understand where life might thrive beyond Earth. On Earth, life was born of planetary processes and has been sustained by plate tectonics and other physical processes. Through evolution, life has in fact emerged as major influence on our planet's surface. Fundamental features of terrestrial life and evolution are addressed in the context of astronomy, planetary physics and chemistry. These, in turn, provide a basis for the exploration for other habitable planets, both within our solar system and in the greater universe.
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4.00 Credits
Fundamental concepts in developmental biology will be presented within the framework of the developing and regenerating mammal. Where possible, lectures will focus on humans.
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4.00 Credits
This course will focus on the biology of organismal cloning, cellular reprogramming, and developmental plasticity. The roll that stem cells play in these processes and the genetic and molecular circuitry that underlie developmental potency and reprogramming will be discussed.
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4.00 Credits
This course will focus on the biology of organ growth and regeneration from a developmental perspective. How is the size and symmetry of our organs set? How does a regenerating animal sense that something is missing and eventually stop the regenerative process when tissues reform? We will learn about conserved developmental pathways that are necessary for adult regeneration and discuss how the aberrant activation of these pathways can lead to overgrowth disorders such as cancer.
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4.00 Credits
The sequencing of the human genome has revealed the full extent of genetic variation that exists within us as a species. This genetic diversity underlies much of our physical variation as well as our differences in responsiveness to disease stimuli and their treatments. We will explore these and other ramifications of human genetic diversity by applying classical and contemporary genetic tools to the identification of specific genes and pathways that functionally underlie our variable biology.
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4.00 Credits
Cloning of Dolly the sheep suggests that all of our cells have exactly the same genes as a fertilized egg. If this is true, then how is it that each of our cells reads out those genes differently? This course will explain the developmental events that regulate the expression of genes, as well as how this developmental expression is established and maintained.
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4.00 Credits
This course will introduce classic experiments and examples of functional RNA genes that comprise the ever-emerging RNA world. We will explore diverse classes of RNA genes and their biochemical mechanisms that have defined field, including overviews of relevant technologies leading to these principal findings. Lecture topics will be followed by students reading and presenting related primary literature. Collectively this course will provide an opportunity to explore the wide spectrum of cellular processes involving RNA molecules.
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