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Course Criteria
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4.00 Credits
This seminar will focus on the neuroscience of sleep. We will begin broadly, by employing a systems-level perspective on the neuroanatomy and neurophysiology of sleep. We will then focus on key regions in detail. We will introduce models of animal research, computational models, neuroimaging, electrophysiology, human disease, and a section on behavioral and cognitive neuroscience of sleep.
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4.00 Credits
Responses to stress are coordinated by the brain and allow organisms to adapt to environmental conditions. When and how can stress responses become maladaptive? This tutorial will explore the roles of psychosocial stress in adaptation, survival, and human disease. We will focus on current approaches to understanding the brain as a mediator of stress response and neurobiological mechanisms of stress-induced plasticity.
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4.00 Credits
The vast array of complex human emotions and behaviors - the spring in your step, the smile in your heart or the chip on your shoulder - can be reduced to electrical impulses in your brain, but what are they really? Through a discussion of primary literature we cover the range of neurons' electrical abilities, how these are used in nervous systems to transmit and encode information, and how these properties can go wrong in channelopathies.
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4.00 Credits
Neural connectivity underlies brain function. This tutorial focuses on discussing and debating research related to how synaptic connections can be influenced by genes, the environment, and chance to generate functional circuits and accommodate learning. In particular we will discuss molecular mechanisms, activity patterns (spontaneous and experience-evoked), and organizational rules implicated in synaptic formation and refinement in the context of many regions within the nervous system (retina, olfatory bulb, cortex, autonomic, and neuromuscular system).
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4.00 Credits
Ever wondered why animals are attracted to the opposite sex, why they attack other animals, or how they decide with whom to mate or to fight? We will study how genetic and neural pathways direct males and females to act the way they do. Topics covered include fighting flies, testosterone-promoted male behavior, same-sex sexual partners, and more. We will also discuss the way sex research is covered by the media and its social implications.
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4.00 Credits
Pharmacology is a cornerstone of treatment for neuropsychiatric disorders. However, the molecular targets of existing antidepressant, anxiolytic, and antipsychotic drugs date from the mid-20th century and yield treatments of limited efficacy. In this seminar we will examine what is known about the mechanism of action of important drug classes and the diseases they treat. We will ask how modern neurobiology and genetics might accelerate much needed progress.
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4.00 Credits
This course is ordinarily taken to obtain credit for independent research leading to a senior thesis. Work should be directed by a member of the Neurobiology concentration standing committee. Other research sponsors must be approved by the Head Tutor and require an appropriate co-sponsor. All students must submit registration materials for Neurobiology 98r at the time of enrollment.
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4.00 Credits
For honors candidates writing a thesis in Neurobiology. This course is ordinarily taken in the last semester of enrollment. The Head Tutor must approve a thesis proposal prior to enrolling in Neurobiology 99.
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4.00 Credits
An integrated approach to the diversity of life, emphasizing how chemical, physical, genetic, ecological and geologic processes contribute to the origin and maintenance of biological diversity. Topics to be covered include the evolution of metabolic pathways, multicellularity and structural complexity; causes and consequences of differences in diversity over space and time; the role of species interactions (including symbioses) as an evolutionary force; and the evolution of humans and their impact on the environment.
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4.00 Credits
In this project based laboratory course students will conduct research utilizing experimental evolution of microbial populations. The research will address questions that sythesize knowledge of genetics, biochemistry, systems biology, microbiology, evolution and ecology.
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