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MCB 154: Advanced Cell and Developmental Biology
4.00 Credits
Harvard University
This course covers topics in molecular and celluar biology within a developmental context. The course is organized around principles of spatial organization within cells, tissues and organs. We will discuss seminal findings as well as important unanswered questions in cell and developmental biology. Each week a different topic will be addressed through a combination of discussion of primary research papers and lectures.
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MCB 154 - Advanced Cell and Developmental Biology
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MCB 155: Bioregulatory Mechanisms
4.00 Credits
Harvard University
An advanced course on the control of gene regulation. Topics include: mechanisms of gene regulation at the level of transcription, chromatin structure, DNA methylation, RNA processing, mRNA localization, and protein synthesis and degradation. The course is taught through weekly lectures and readings from the current literature. Topics covered in lectures and the reading assignments are discussed in sections. Students are required to critically evaluate and discuss recent papers in sections. Two exams.
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MCB 155 - Bioregulatory Mechanisms
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MCB 156: Structural Biology of the Flow of Information in the Cell
4.00 Credits
Harvard University
A journey that follows the path taken by an extra-cellular signal as it reaches a cell, traverses the plasma membrane, navigates the cytoplasm, and finally manifests its effect upon the genome. Through the reading and discussion of primary research literature, the course highlights how structural biology has helped develop a detailed picture of each step in the pathway. The interplay between cellular and network biology and structural biology is also emphasized.
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MCB 156 - Structural Biology of the Flow of Information in the Cell
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MCB 169: Molecular and Cellular Immunology
4.00 Credits
Harvard University
The immune system is frontier at which molecular biology, cell biology, and genetics intersect with the pathogenesis of disease. The course examines in depth the cellular and molecular mechanisms involved in the development and function of the immune system and also analyzes the immunological basis of human disease including AIDS and other infectious diseases, autoimmune disorders, allergic disorders, primary immunodeficiency syndromes, transplantation, and cancer.
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MCB 169 - Molecular and Cellular Immunology
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MCB 176: Biochemistry of Membranes
4.00 Credits
Harvard University
A course on the properties of biological membranes, essential elements for cell individuality, communication between cells, and energy transduction. Topics include: membrane structure; membrane protein synthesis, insertion in the bilayer and targeting; transporters, pumps and channels; electron transport, H+ gradients and ATP synthesis; membrane receptors, G proteins and signal transduction; membrane fusion.
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MCB 176 - Biochemistry of Membranes
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MCB 185: Human Disease
4.00 Credits
Harvard University
This course will address both the molecular basis of human disease and the biological and chemical foundation of therapeutic intervention. The course will include lectures by prominent experts and analysis of the primary literature.
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MCB 185 - Human Disease
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MCB 186: Circadian Biology: From Cellular Oscillators to Sleep Regulation
4.00 Credits
Harvard University
Properties, mechanisms, and functional roles of circadian (daily) rhythms in organisms ranging from unicells to mammals. Cellular and molecular components, regulation of gene expression and physiological functions, genetic and biochemical analyses of circadian rhythms, and neurobiology of the mammalian circadian pacemaker. Mathematics and modeling of oscillatory systems and applications to circadian rhythms. Experimental studies of human rhythms, including the sleep-wake cycle and hormone rhythms, with applications to sleep disorders.
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MCB 186 - Circadian Biology: From Cellular Oscillators to Sleep Regulation
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MCB 188: Chromosomes
4.00 Credits
Harvard University
Chromosome morphogenesis in prokaryotic and eukaryotic organisms. Topics will include chromosome structure, interactions between chromosomes (sisters and homologs), DNA recombination and repair, topoisomerases, transposable elements and site-specific recombination, epigenetic inheritance. Genetic, cytological, and biochemical approaches will be integrated. Lecture, reading, and discussion of classical and current literature and consideration of future experimental directions.
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MCB 188 - Chromosomes
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MCB 198: Advanced Mathematical Techniques for Modern Biology
4.00 Credits
Harvard University
How do we find biologically meaningful patterns in a large amount of data? How do animals learn to use patterns in the environment to infer information despite the ignorance of the underlying laws? The course will introduce Bayesian analysis, maximum entropy principles, hidden markov models and pattern theory in order to study DNA sequence, gene expression and neural spike train data. The relevant biological background will be covered in depth.
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MCB 198 - Advanced Mathematical Techniques for Modern Biology
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MCB 199: Statistical Thermodynamics and Quantitative Biology
4.00 Credits
Harvard University
Course seeks to develop an understanding of thermodynamics and statistical mechanics, with applications to quantitative problems in biology such as configurations of biopolymers, equilibrium states of matter, chemical reactions and protein transport, using the concepts of entropy, free energy, adsorption, chemical kinetics and molecular diffusion.
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MCB 199 - Statistical Thermodynamics and Quantitative Biology
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