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Course Criteria
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3.00 Credits
Living organisms require constant input of energy and raw materials, acquired from their surroundings and harnessed by numerous metabolic pathways. An ever-increasing knowledge of the integration and regulation of these pathways has deepened our understanding of both health and disease. Using studies from recent research and articles from the popular press, and based on fundamental biochemistry, we will investigate various topics: the increase in obesity and diabetes, the metabolism of cholesterol, inborn errors of metabolism, the connection between how we eat and the global carbon cycle, the sense or nonsense of nutritional supplementation, and the evolution of metabolic pathways.
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3.00 Credits
Developmental biology is in the midst of a far-reaching revolution that profoundly affects many related disciplines including evolutionary biology, morphology, and genetics. The new tools and strategies of molecular biology have begun to link genetics and embryology and to reveal an incredible picture of how cells, tissues, and organisms differentiate and develop. This course describes both organismal and molecular approaches which lead to a detailed understanding of (1) how it is that cells containing the same genetic complement can reproducibly develop into drastically different tissues and organs, and (2) the basis and role of pattern information in this process.
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4.00 Credits
This course will examine the normal functions of a living human organism including its physical and chemical processes. An integrative approach will be used to explore the physiologcal processes of the nervous, respiratory, cardiovascular, renal, gastrointestinal and endocrine systems and the relationships between them. In the computer based laboratory, which is a corequisite, students will investigate the functions of intact, living human organisms through real-time, hands-on data acquisition and analysis of the neuromuscular, cardiovascular and respiratory systems using clinical measurements including EMG, EEG, cardiac electrophysiology and spirometry.
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3.00 Credits
This course is designed to introduce biology and biochemistry majors to the subject with an emphasis on understanding the biochemical principals that are crucial to biological function at the molecular, cellular, and organismal levels. The material includes: (1) the structure and chemistry of biomolecules, including amino acids, proteins, lipids, carbohydrates, and nucleic acids; (2) the key metabolic pathways and enzymology involved in the synthesis/degradation of carbohydrates; and (3) the cycling of energy through biological systems. Reference will be made to alterations in biochemical structures, processes, and pathways that relate to specific diseases.
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3.00 Credits
This course is an intermediate-level course in molecular biology with emphasis on the relationship between three-dimensional structure and function of proteins and nucleic acids. Topics will include the following: physical methods for the study of macromolecules, protein folding motifs and mechanisms of folding, molecular recognition, DNA topology, replication, repair and recombination, RNA synthesis and processing, genetic code and translation, and molecular mechanisms for regulation of gene expression.
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3.00 Credits
Students in Ecology will investigate interrelationships among organisms, and between organisms and their physical environments. Students will become familiar with looking at ecological processes on a hierarchy of interconnected levels, including those of the molecule, individual, population, community, and ecosystem. The class will discuss classic experiments in ecology, as well as unresolved ecological questions of special current relevance. There will be an emphasis on developing a conceptual understanding of ecological relationships, on exploring the analytical tools with which ecological hypotheses are generated and tested, and on appreciating the dynamic nature of populations and ecosystems.
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3.00 Credits
This course will focus on the behavior of animals under natural conditions with an emphasis on both mechanistic and evolutionary approaches. Lectures and readings from the primary literature will address major studies in ethology including: learning and memory, communication, orientation and migration, optimal foraging, sexual selection, parental investment, mating systems, anti-predator behavior, and sociality.
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3.00 Credits
The onset of cancer occurs through a multi-step process that is accompanied by the deregulation of fundamental cellular processes, including cell cycle control, apoptosis, and angiogenesis. This course will provide an overview of the molecular and cellular changes associated with these processes and with the initiation, progression, and metastasis of tumors. Topics covered will include tumorigenesis, tumor viruses, oncogenes, tumor suppressor genes, genomic instability, and the current treatments for cancer. The class will draw on textbook and primary literature readings to enrich the current view of this complex disease.
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3.00 Credits
An introductory survey of the immune system, this course will examine the development and deployment of immunity from a molecular and cellular perspective. Topics will include innate versus adaptive immunity, B and T cell activation, antibodies and antigens, and immunological memory. Modern experimental techniques and the immune system's roles in infectious disease, cancer, and autoimmune disease will also be discussed.
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3.00 Credits
Students will explore major ideas in modern evolutionary biology, including natural selection, mutation and genetic variation, population genetics, architectural constraints on structure, speciation and adaptive radiation, the history of life, and the evolution of sociality. The emphasis will be on learning conceptual tools that can be applied to specific questions and on an integrative understanding of the complexity of evolutionary change. For example, students will combine thinking from population genetics and developmental biology with ideas from phylogenetics and ecology. Important practical implications of evolution, such as the evolution of infectious diseases and the evolution of agricultural pests, will be explored.
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