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Biological Sciences 99: Tutorial
1.25 Credits
University of California-Santa Cruz
Individual, directed study for undergraduates. Students submit petition to sponsoring agency. May be repeated for credit. The Staff
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Biomolecular Engineering 109: Resource-Efficient Programming
1.25 Credits
University of California-Santa Cruz
Writing programs that use computer resources efficiently. Learn to measure resource usage and modify programs to get better performance. Particularly appropriate for programmers working at limits of their hardware (bioinfor-maticians, game programmers, and embedded system programs). Prerequisites(s): Computer Science 12B and 12M or 13H and 13L, Computer Engineering 16 or 16H, and Mathematics 19A. Enrollment limited to 90. K. Karplus
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Biomolecular Engineering 109 - Resource-Efficient Programming
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Biomolecular Engineering 110: Computational Biology Tools. W
1.25 Credits
University of California-Santa Cruz
Hands-on laboratory geared to teach basic tools used in computational biology (motif searching, primer selection, sequence comparison, multiple sequence alignment, genefinders, phylogenetics analysis, X-ray crystallography software). Web- and Unix-based tools/databases are used. Open to all science students; no prior Unix experience required. (Also offered as Biology: Molecular Cell & Dev 181. Students cannot receive credit for both courses.) Prerequisite(s): Biology 20B and Chemistry 1C Enrollment limited to 25. T. Lowe, D. Gerloff
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Biomolecular Engineering 123A: Engineering Design Project I
2.00 Credits
University of California-Santa Cruz
First of a two-course sequence that is the culmination of the engineering program. Students apply knowledge and skills gained in elective track to complete a major design project. Students complete research, specification, planning, and procurement for a substantial project. Includes technical discussions, design reviews, and formal presentations; engineering design cycle, engineering teams, and professional practices. Formal technical specification of the approved project is presented to faculty. Prerequisite(s): Electrical Engineering 171 or Computer Engineering 121; previous or concurrent enrollment in Computer Engineering 185; permission of department and instructor. Students are billed a materials fee. (Also offered as Electrical Engineering 123A and Computer Engineering 123A. Students cannot receive credit for all courses.) The Staff
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Biomolecular Engineering 123B: Engineering Design Project II. W
7.00 Credits
University of California-Santa Cruz
Second of two-course sequence in engineering system design. Students fully implement and test system designed and specified in course 123A. Formal written report, oral presentation, and demonstration of successful project to review panel of engineering faculty required. Students are billed a materials fee. (Also offered as Electrical Engineering 123B and Computer Engineering 123B. Students cannot receive credit for all courses.) Prerequisite(s): course 123A and Computer Engineering 185. Enrollment limited to 35. The Staff
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Biomolecular Engineering 130: Genomes
1.25 Credits
University of California-Santa Cruz
Advanced elective for biology majors, examining biology on the genome scale. Topics include genome sequencing; large scale computational and functional analysis; features specific to prokaryotic, eukaryotic, or mammalian genomes; proteomics; SNP analysis; medical genomics; and genome evolution. Prerequisite(s): Biology 100 or Biochemistry 100A and Biology 105, or approval of instructor. Enrollment limited to 30. T. Lowe
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Biomolecular Engineering 130 - Genomes
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Biomolecular Engineering 140: Bioinstrumentation
1.25 Credits
University of California-Santa Cruz
Introduction to theory, design, and application of bioinstrumentation in clinical, pharmaceutical, and biotechnology laboratories. Highly recommended for students planning careers in the biomolecular industries. Typical topics and demonstrations include thermocycler, polymerase chain reaction (PCR), pyrosequencing, fabless nanofabrication, ion-sensitive measurements, microarray fabrication, and fluorescent-activated cell sorter (FACS). Prerequisite(s): course 5, or Biology 100, or Biochemistry and Molecular Biology 100A. N. Pourmand
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Biomolecular Engineering 150: Molecular Biomechanics
1.25 Credits
University of California-Santa Cruz
Considers how assemblies of macromolecules (molecular motors) convert chemical energy into mechanical work on the nanometer-to-Angstrom scale. Processes examined include ATP-dependent movement of organelles in the cytocsol facilitated by kinesin; proton pumping by ATPases in the mitochondrial membrane; viral genome packaging; bacterial movement driven by flagella; pro-cessive addition of nucleotides by polymerases during replication and transcription; and protein synthesis by ribosomes. Cannot receive credit for this course and course 250. Prerequisite(s): Biology 20A; and Biology 20B or 105; and Biology 100 or Biochemistry 100A; and Physics 5C or 6C. Concurrent enrollment in course 150L required. H. Wang, M. Akeson, W. Dunbar
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Biomolecular Engineering 150 - Molecular Biomechanics
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Biomolecular Engineering 150L: Molecular Biomechanics Laboratory
2.00 Credits
University of California-Santa Cruz
Students address a current scientific question about molecular motor function using techniques established in the UCSC Nanopore Laboratory. Specifically, students use recombinant DNA technology to produce an enzyme (e.g., a DNA polymerase) bearing a point mutation that is predicted to alter function in a defined manner. Students then use nanopore force spectroscopy to model the energy landscape for a mechanical or chemical step altered by the critical amino acid. Cannot receive credit for this course and course 250L. Prerequisite(s): Biology 20A; and Biology 20B or 105; and Biology 100 or Biochemistry 100A; and Physics 5C or 6C. Concurrent enrollment in course 150 required. H. Wang, M. Akeson, W. Dunbar
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Biomolecular Engineering 155: Biotechnology and Drug Development.W
1.25 Credits
University of California-Santa Cruz
Recommended for students interested in careers in the biopharmaceutical industry. Focuses on recombinant DNA technology and the drug-development process, including discovery research; preclinical testing; clinical trials; and regulatory review, as well as manufacturing and production considerations. Students may not receive credit for this course and course 255. (Also offered as Biology: Molecular Cell & Dev 179. Students cannot receive credit for both courses.) Prerequisite(s): Biology 20A and Biology 100 or Biochemistry and Molecular Biology 100A. Enrollment limited to 15. P. Berman
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