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Course Criteria
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4.00 Credits
Lecture, three hours; discussion, one hour. Chemistry of macromolecules; emphasis on proteins. Physical and chemical properties of proteins, forces that maintain protein structure, relationship between structure and function, interactions of proteins with ligands and other macromolecules, and experimental methods to study structure, function, and interactions. Corequisite: Chemistry 130A or 131A. Prerequisites: Biological Sciences 98 and 99. Concurrent with Molecular Biology 240.
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4.00 Credits
Lecture, three hours. Introduction to human animal-parasitic diseases including worms and protozoan infections. Prerequisite: Biological Sciences 99. Formerly Biological Sciences D143.
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4.00 Credits
Lecture, three hours. Structure, function, and biogenesis of biological membranes and membrane-bound organelles; protein trafficking and transmembrane signaling. Prerequisite: Biological Sciences D103.
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4.00 Credits
Lecture, three hours. Integral membrane proteins such as voltage and ligand-gated ion channels, water channels, pumps, cotransporters, and receptors (e.g., GPCRs). The emphasis is on the relationship between atomic structure and the functional properties of these proteins. Prerequisites: a grade of B or better in Biological Sciences 98 and 99. Concurrent with Molecular Biology and Biochemistry 255.
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4.00 Credits
Lecture, three hours; discussion, one hour. Molecular basis of drug-receptor action at the molecular and cellular levels. Structure-function of drug targets emphasizing enzymes, ion channels, and membrane transport proteins. Understanding how the drugs' mechanisms of action contribute to the development of more efficacious and safer drugs. Prerequisites: Chemistry 51B, Biological Sciences E109 and 98 or Chemistry 128. Same as Pharmaceutical Sciences M170A.
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4.00 Credits
Lecture, three hours; discussion, one hour. Mechanism-based overview of pharmacology and therapeutic drugs in the fields of autonomic nervous system, central nervous system, and antimicrobials. Prerequisites: Biological Sciences 99, E109, and M170A; and Chemistry 51C. Same as Pharmaceutical Sciences M170B.
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4.00 Credits
Lecture, three hours; discussion, one hour. Principles in quantum mechanics and applications in biomolecular spectroscopy; rotational, vibrational, electric, and magnetic resonance. Principles of statistical mechanics and chemical thermodynamics; energy, entropy, free energy, and equilibrium for biological reactions. Principles of kinetics for biochemical reactions. Prerequisites: Biological Sciences 99, Chemistry 1C, Mathematics 2B, and Physics 3B. Same as Pharmaceutical Sciences M171.
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2.00 Credits
Lecture, two hours. Presents information about various fields of research, study, careers, and graduate school opportunities in pharmaceutical sciences. Taught by guest lecturers from various disciplines including 199 research course faculty. Helps Pharmaceutical Sciences students select electives appropriate to their future goals. Prerequisites: Biological Sciences 99, 100L, and Chemistry 51C. Pass/Not Pass only. Same as Pharmaceutical Sciences M172.
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4.00 Credits
Lecture, three hours; discussion, one hour. An exploration of the clinical application of medications to selected disease states. Focus is on an understanding of underlying principles of pharmacology and how this knowledge can be applied to treatment of diseases. Prerequisites: Biological Sciences M170A and M170B, or Pharmaceutical Sciences M170A and M170B. Same as Pharmaceutical Sciences M173.
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4.00 Credits
Lecture, three hours; discussion, one hour. Introduces theories and tools of new drug formulations. Particularly new novel therapeutics based on biological materials, pathological characteristics utilized to achieve the maximum efficacy and specificity, and drug delivery systems are extensively discussed. Prerequisites: Biological Sciences M170A and M170B, or Pharmaceutical Sciences M170A and M170B, or consent of instructor. Same as Pharmaceutical Sciences M174.
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