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Course Criteria
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3.00 Credits
CHEM 715. Advanced Spectroscopy I An introduction to 1H and 13C NMR spectroscopy including basic concepts such as integration, chemical shifts, diamagnetic shielding, magnetic anisotropy, spin-spin coupling (first and second-order), coupling constants, proton decoupled 13C NMR interpretation of 1H and 13C NMR spectra. More advanced topics include NOE and protein structural mapping, and multidimensional techniques such as COSY, DEPT, INEPT, molecular motion by NMR, coupling to 1>0 metal centers, including those with <100 percent natural abundance, virtual coupling in metal complexes, NMR of paramagnetic systems and use of paramagnetic shift reagents. An introduction to mass spectroscopy including instrumentation¿magnetic sector, quadrupole, ion trap, MS-MS; sample preparation and interfaces¿GC-MS, LC-MS, electrospray, MALDI; methods of ionization¿electron impact, chemical ionization, electrospray, interpretation of mass spectra¿basic concepts, fragmentation patterns. An introduction to the interpretation of mid-infrared spectroscopy of complex molecules and ionic compounds followed by the synthesis of results from NMR, MS and mid IR spectra to determine structure. Emphasis on interpretation of results for understanding electronic and molecular properties of chemical compounds related to their symmetry.
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3.00 Credits
CHEM 717. Advanced Spectroscopy II An introduction to electronic and vibrational spectroscopy, EPR and magnetic properties of compounds. A study of the electric field interaction of radiation, electronic and vibrational spectroscopy, and the magnetic field interaction of radiation, EPR and magnetism, with molecular systems examining the different changes in state that molecules can undergo. Emphasis on interpretation of results for understanding electronic and molecular properties of chemical compounds related to their symmetry and structure.
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3.00 Credits
CHEM 719. Modern Synthetic Methods An introduction to modern synthetic methods in chemistry. A detailed investigation of the synthetic chemistry of anions is followed by a detailed survey of functional group interconversions, then oxidation and reduction reactions. The topic of retrosynthetic analysis is introduced. Topics in inorganic synthesis include organometallic bond forming and breaking reactions, ligand synthesis and replacement, solid state synthesis, and topics in bioinorganic synthesis.
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3.00 Credits
CHEM 721. Advanced Biochemistry An introduction to advanced biochemical concepts, processes, and techniques. A comprehensive survey of structure functions of biomolecules including proteins, nucleic acids, lipids and carbohydrates is carried out. Protein synthesis, DNA replication and translation, biological membrane and membrane transport are covered. Enzyme mechanisms and kinetics and protein structure/function are discussed in detail. Biochemical, molecular biological, biophysical, and chemical techniques that are commonly used in the study of biochemical processes are introduced and discussed.
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3.00 Credits
Physical Organic Chemistry Discussion of advanced topics in stereochemistry and conformational analysis and organic reaction mechanisms. Prerequisite: CHEM 532.
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3.00 Credits
Advanced Organic Synthesis Discussion of modern synthetic methods in organic chemistry, including carbon-carbon forming reactions, oxidation and reduction reactions, protective groups, and organometallic chemistry. Prerequisite: CHEM 532.
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3.00 Credits
CHEM 734. Instrumental Methods for Research Designed to prepare graduate students or other researchers to perform spectroscopy experiments relevant to their research. The identity of organic compounds can be determined by the information provided by several types of spectra: mass, infrared, nuclear magnetic resonance, fluorescence, and ultraviolet. Students will learn to operate such instruments as the Varian 2200 GC/MS mass spectrometer, the ThermoNicolet Avatar FTIR spectrophotometer, the Varian Mercury 300 and Inova 400 NMR spectrometers, the Fluorolog fluorescence spectrophotometer and the Hitachi U-2010 and Varian Cary 100 UV-Vis spectrophotometers in the department¿s NMR and analytical facilities. The focus of this class is technique and not the interpretation of spectra. On successful completion of this course, students are authorized to use departmental instruments. Prerequisite: departmental consent.
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3.00 Credits
Structure Determination and Spectral Analysis of Organic Compounds Discusses chiroptical techniques, infrared, ultraviolet, nuclear magnetic and electron spin resonance and mass spectroscopy, and their practical use in structure determination. Prerequisite: CHEM 532.
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3.00 Credits
No course description available.
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3.00 Credits
CHEM 744. Computational Quantum Chemistry An introduction to molecular orbital procedures and methods for calculating a wide range of physical, chemical, and electronic properties of systems large enough to be of interest to inorganic, organic, and biochemists. Using commercial molecular orbital software programs such as MOPAC, SPARTAN, and GAUSSIAN, students learn to select appropriate "model" computational procedures to predict properties of molecules and reactions. By comparison with experiment, students learn to assess the range of applicability and accuracy of the "model" methods as applied to various categories of chemical systems. Properties considered include energies and structures of molecules, ions, and transition states; vibrational frequencies, IE and RAMAN spectra; thermochemical properties, heat of formation, bond and reaction energies, isomerization energy barriers; reaction pathways; molecular orbitals, atomic charges, dipole and multipole moments, ionization potentials, bond orders; orbital energies and photoelectron spectroscopy; excited state properties, singlet and triplet surfaces. Prerequisite: CHEM 546 or equivalent (MATH 344 is necessary).
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