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Course Criteria
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3.00 Credits
Anna Marie Pyle, Donald Engelman, A. Elizabeth Rhoades, Hongwei Wang. mw 11.35-12.50, 1 htba Sc (34) Examination of the dynamic properties, interactions, and catalytic activities of macromolecules. Topics include macromolecular folding; binding interfaces; lig-and interactions; the properties of membrane proteins, enzymes, ribozymes, and molecular motors; and modern methods for analysis of macromolecular associations and dynamic properties. Prerequisites: mb&b 301b and 302b.
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3.00 Credits
Shirleen Roeder, and staff. mw 11.35-12.50 Sc (0) An examination of the universal principles of genetic analysis in eukaryotes. Reading and analysis of primary papers illustrating the best of genetic analysis in the study of a variety of biological issues. Focus on the concepts and logic underlying modern genetic analysis. Prerequisite: mcdb 200b or equivalent.
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3.00 Credits
A. Elizabeth Rhoades, Corey O'Hern, Yong Xiong. mwf 10.30-11.20 QR,Sc (0) Applied mathematical methods relevant to analysis and interpretation of biophysical and biochemical data. Statistics and error analysis, differential equations, linear algebra, and Fourier transforms. Analysis of real data from research groups in MB&B. Prerequisites: math 120a or b and mb&b 300a or equivalents, or with permission of instructors.
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3.00 Credits
Mark Hochstrasser, Anthony Koleske, Patrick Sung. tth11.35-12.50 Sc Meets RP (24) Selected topics in regulation of chromatin structure and remodeling, mrna processing, mrna stability, translation, protein degradation, dna replication, dna repair, site-specific dna recombination, and somatic hypermutation. Prerequisites: mb&b 300a and 301b, or permission of instructor.
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3.00 Credits
Anthony Koleske, Nigel Grindley, Mark Hochstrasser, Dieter S?ll. th 7-8.50 p.m. Sc Meets RP (0) An examination of fundamental concepts in molecular biology through analysis of landmark papers. Development of skills in reading the primary scientific literature and in critical thinking. Prerequisites: mb&b 300a and 301b.
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3.00 Credits
Joan Steitz, Mark Hochstrasser, Lynne Regan, David Schatz. mw1-2.15 Sc (0) Examples of recent discoveries in basic science that have elucidated the molecular origins of disease or that have suggested new therapies for disease. Readings from the primary scientific and medical literature, with emphasis on developing the ability to read this literature critically. Prerequisites: mb&b 300a and 301b or equivalent, or permission of instructor
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3.00 Credits
Mark Gerstein. mw1-2.15 Sc (0) Techniques in data mining and simulation applied to bioinformatics, the computational analysis of gene sequences, macromolecular structures, and functional genomics data on a large scale. Sequence alignment, comparative genomics and phylogenetics, biological databases, geometric analysis of protein structure, molecular-dynamics simulation, biological networks, microarray normalization, and machine-learning approaches to data integration. Prerequisites: mb&b 301b and math 115a or b, or permission of instructor
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2.00 Credits
Alan Garen and staff. htba (0) Individual laboratory projects under the supervision of a faculty member. Students must submit an enrollment form that specifies the research supervisor by the date that course schedules are due. A required organizational meeting will be held at the beginning of each term. Students are expected to commit at least ten hours per week to working in a laboratory. Written assignments include a research proposal, due near the beginning of the term, and a research report that summarizes experimental results, due before the beginning of the final examination period. No more than two course credits count as electives toward the B.S. degree. Enrollment limited to junior and senior MB&B majors. Prerequisite: mb&b 251La or 360Lb.
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3.00 Credits
Alan Garen and staff. htba 2 C Credits per term (0) Individual laboratory projects under the supervision of a faculty member. Students must submit an enrollment form that specifies the research supervisor by the day that course schedules are due. A required organizational meeting will be held at the beginning of each term. Students are expected to commit at least twenty hours per week to working in a laboratory. Written assignments include a research proposal, due near the beginning of the term, and a research report that summarizes experimental results, due before the beginning of the final examination period. No more than two course credits count as electives toward the B.S. degree. Enrollment limited to senior MB&B majors. Prerequisite: mb&b 251La or 360Lb.
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3.00 Credits
Andrew Miranker, HongweiWang. htba (0) Colloquium for fulfillment of the senior requirement. The course involves a written and an oral presentation of a senior paper in an area of biochemistry or biophysics. The topic is selected in consultation with the faculty members in charge of the course.
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