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Course Criteria
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4.00 Credits
Lecture, four hours; discussion, one hour. Requisite: course 110B or 156. Recommended: course 113A. Rigorous presentation of fundamentals of classical thermodynamics. Principles of statistical thermodynamics: probability, ensembles, partition functions, independent molecules, and perfect gas. Applications of classical and statistical thermodynamics selected from diatomic and polyatomic gases, solid and fluid states, phase equilibria, electric and magnetic effects, ortho-para hydrogen, chemical equilibria, reaction rates, imperfect gas, nonelectrolyte and electrolyte solutions, surface phenomena, high polymers, gravitation. May be concurrently scheduled with courses C223A-C223B. P/NP or letter grading.
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4.00 Credits
Lecture, four hours; laboratory, four hours. Preparation: programming experience in either BASIC, Fortran, C, C++, Java, or Pascal. Requisites: course 110A, Mathematics 33B. Theoretical, numerical, and programming tools for constructing new chemical applications, including simple force fields and resulting statistical mechanics for simple molecules, simple abinitio methods for organic molecules and nanotubes, and classical dynamics and spectroscopy. Concurrently scheduled with course C226A. P/NP or letter grading.
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4.00 Credits
Lecture, three hours. Requisites: courses 30C, 110A. Basic physical, chemical, and biological principles in bionanotechnology; materials and strategies for top-down and bottom-up fabrication of ordered biologically derived molecules, characterization and detection techniques, and biomimetic materials and applications at nanoscale. Concurrently scheduled with course C240. P/NP or letter grading.
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4.00 Credits
Lecture, three hours; discussion, one hour. Requisites: courses 30C and 30CL (may be taken concurrently), 110B, and 113A, with grades of C- or better. Mechanisms of organic reactions. Acidity and acid catalysis; linear free energy relationships; isotope effects. Molecular orbital theory; photochemistry; pericyclic reactions. May be concurrently scheduled with course C243A. P/NP or letter grading.
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4.00 Credits
Lecture, three hours; discussion, one hour. Requisite: course C143A with grade of C- or better. Mechanisms of organic reactions; structure and detection of reactive intermediates. May be concurrently scheduled with course C243B. P/NP or letter grading.
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4.00 Credits
Lecture, two hours; discussion, one hour; computer laboratory, one hour. Requisites: courses 30C, 113A. Applications of quantum mechanical concepts and methods to understand and predict organic structures and reactivities. Computational modeling methods, including laboratory experience with force-field and quantum mechanical computer calculations. Concurrently scheduled with course C245. P/NP or letter grading.
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2.00 Credits
First five weeks. Lecture, four hours. Requisites: courses 153B, 154. Mechanisms that control transcription in bacteria. Repression and activation at promoters. Sigma factors and polymerase binding proteins. Signal transduction pathways in transcription. Control of termination. Concurrently scheduled with course C259A. P/NP or letter grading.
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2.00 Credits
Second five weeks. Lecture, four hours. Requisite: course C159A. Eukaryotic general transcriptional apparatus; sequence-specific promoter recognition; mechanisms of transcriptional activation and repression, including role of chromatin structure; transcription factors as targets of signal transduction pathways; transcription factors in embryogenesis. Concurrently scheduled with course C259B. P/NP or letter grading.
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4.00 Credits
Lecture, four hours; laboratory, four hours. Enforced requisite: course C160A with grade of C- or better. Recommended: Program in Computing 60, Statistics 100A, 110A. Development and application of computational approaches to biological questions. Understanding of mechanisms for determining statistical significance of computationally derived results. Development of foundation for innovative work in bioinformatics and systems biology. Concurrently scheduled with course C260B. P/NP or letter grading.
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4.00 Credits
Lecture, three hours; discussion, one hour. Requisite: course 153C. Introduction to distinctive features of plant biochemistry. Topics include photosynthesis, nitrogen metabolism, plant cell wall metabolism, and secondary metabolism in relation to stress. Concurrently scheduled with course C261A. P/NP or letter grading.
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