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Course Criteria
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4.00 Credits
Lecture, three hours; discussion, one hour. Enforced requisite: course 14C with grade of C- or better. Organic reactions, nucleophilic and electrophilic substitutions and additions; electrophilic aromatic substitutions, carbonyl reactions, catalysis, molecular basis of drug action, and organic chemistry of pharmaceuticals. P/NP or letter grading.
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4.00 Credits
Lecture, four hours; discussion, one hour. Requisite: course 14D or 30B, with grade of C- or better. Recommended: Life Sciences 2, 3. Structure of proteins, carbohydrates, and lipids; enzyme catalysis and principles of metabolism, including glycolysis, citric acid cycle, and oxidative phosphorylation. P/NP or letter grading.
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4.00 Credits
Lecture, three hours; discussion, one hour; tutorial, one hour. Requisite: course 14D or 30B, with grade of C- or better. Recommended: Life Sciences 2, 3. Honors course parallel to course 153A. P/NP or letter grading.
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4.00 Credits
Lecture, three hours; discussion, one hour; tutorial, one hour. Requisites: course 153A or 153AH, Life Sciences 2, 3. Nucleotide metabolism; DNA replication; DNA repair; transcription machinery; regulation of transcription; RNA structure and processing; protein synthesis and processing. P/NP or letter grading.
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4.00 Credits
Lecture, three hours; discussion, one hour; tutorial, one hour. Requisites: course 153A or 153AH, Life Sciences 2, 3. Honors course parallel to course 153B. P/NP or letter grading.
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4.00 Credits
Lecture, three hours; discussion, one hour; tutorial, one hour. Requisite: course 153A or 153AH. Metabolism of carbohydrates, fatty acids, amino acids, and lipids; photosynthetic metabolism and assimilation of inorganic nutrients; regulation of these processes. P/NP or letter grading.
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4.00 Credits
Lecture, three hours; discussion, two hours. Requisite: course 153A or 153AH. Honors course parallel to course 153C. P/NP or letter grading.
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4.00 Credits
Lecture, two hours; laboratory, four hours. Enforced requisites: courses 14CL and 14D, or 30B and 30BL, and 153A or 153AH (may be taken concurrently), with grades of C- or better. Integrated term-long project involving characterization of enzyme purified from meat obtained at local butcher. Techniques include ammonium sulfate fractionation, affinity chromatography, protein and enzyme assays, polyacrylamide gel electrophoresis, gel exclusion chromatography, and enzyme kinetic analysis. P/NP or letter grading.
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5.00 Credits
Lecture, two hours; laboratory, eight hours. Enforced requisites: courses 153A or 153AH, 153B or 153BH, and 153L, with grades of C- or better. Recommended: course 156. Two to three major laboratory projects using biochemical laboratory techniques to investigate contemporary problems in biochemistry. Topics include transcription activation, molecular basis of DNA-protein interactions, biochemical basis of platelet activation, and initiation of blood clotting cascade. Experiments entail characterizing function of proteins, nucleic acids, and lipids involved in these processes. P/NP or letter grading.
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4.00 Credits
Lecture, four hours; discussion, one hour. Requisites: courses 110A, 153A. Biochemical kinetics; solution thermodynamics of biochemical systems; multiple equilibria; hydrodynamics; energy levels, spectroscopy, and bonding; topics from structural, statistical, and electrochemical methods of biochemistry. P/NP or letter grading.
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