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Course Criteria
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3.00 Credits
Tutorial, to be arranged. Limited to juniors/seniors. Supervised individual research or investigation under guidance of faculty mentor. Culminating paper or project required. May be repeated for credit with school approval. Individual contract required; enrollment petitions available in Office of Academic and Student Affairs. Letter grading.
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4.00 Credits
Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 30A, Life Sciences 2, 3. To understand biological materials and design synthetic replacements, it is imperative to understand their physical chemistry. Biomacromolecules such as protein or DNA can be analyzed and characterized by applying fundamentals of polymer physical chemistry. Investigation of polymer structure and conformation, bulk and solution thermodynamics and phase behavior, polymer networks, and viscoelasticity. Application of engineering principles to problems involving biomacromolecules such as protein conformation, solvation of charged species, and separation and characterization of biomacromolecules. Letter grading.
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4.00 Credits
Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Chemistry 20A, 20B, 20L. Highly recommended: one organic chemistry course. Bioconjugate chemistry is science of coupling biomolecules for wide range of applications. Oligonucleotides may be coupled to one surface in gene chip, or one protein may be coupled to one polymer to enhance its stability in serum. Wide variety of bioconjugates are used in delivery of pharmaceuticals, in sensors, in medial diagnostics, and in tissue engineering. Basic concepts of chemical ligation, including choice and design of conjugate linkers depending on type of biomolecule and desired application, such as degradable versus nondegradable linkers. Presentation and discussion of design and synthesis of synthetic bioconjugates for some sample applications. Letter grading.
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4.00 Credits
Lecture, three hours; discussion, one hour; outside study, eight hours. Requisites: Chemistry 14C, Life Sciences 1, 2, 3, 4, Mathematics 33B, Physics 1C, 4AL, 4BL. Coverage in depth of physical processes associated with biological membranes and channel proteins, with specific emphasis on electrophysiology. Basic physical principles governing electrostatics in dielectric media, building on complexity to ultimately address action potentials and signal propagation in nerves. Topics include Nernst/Planck and Poisson/Boltzmann equations, Nernst potential, Donnan equilibrium, GHK equations, energy barriers in ion channels, cable equation, action potentials, Hodgkin/ Huxley equations, impulse propagation, axon geometry and conduction, dendritic integration. Letter grading.
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4.00 Credits
Lecture, four hours; discussion, one hour; outside study, seven hours. Requisites: courses 100, 120, Life Sciences 2, 3, Physics 1A, 1B, 1C. Analysis of sensors based on measurements of fluctuating ionic conductance through artificial or protein nanopores. Physics of pore conductance. Applications to single molecule detection and DNA sequencing. Review of current literature and technological applications. History and instrumentation of resistive pulse sensing, theory and instrumentation of electrical measurements in electrolytes, nanopore fabrication, ionic conductance through pores and GHK equation, patch clamp and single channel measurements and instrumentation, noise issues, protein engineering, molecular sensing, DNA sequencing, membrane engineering, and future directions of field. Letter grading.
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4.00 Credits
Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 30B, Life Sciences 2, 3, Mathematics 32A. Introduction to design principles and engineering concepts used in design and manufacture of tools for minimally invasive surgery. Coverage of FDA regulatory policy and surgical procedures. Topics include optical devices, endoscopes and laparoscopes, biopsy devices, laparoscopic tools, cardiovascular and interventional radiology devices, orthopedic instrumentation, and integration of devices with therapy. Examination of complex process of tool design, fabrication, testing, and validation. Preparation of drawings and consideration of development of new and novel devices. Letter grading.
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4.00 Credits
Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 20L. New therapeutics require comprehensive understanding of modern biology, physiology, biomaterials, and engineering. Targeted delivery of genes and drugs and their controlled release are important in treatment of challenging diseases and relevant to tissue engineering and regenerative medicine. Drug pharmacodynamics and clinical pharmacokinetics. Application of engineering principles (diffusion, transport, kinetics) to problems in drug formulation and delivery to establish rationale for design and development of novel drug delivery systems that can provide spatial and temporal control of drug release. Introduction to biomaterials with specialized structural and interfacial properties. Exploration of both chemistry of materials and physical presentation of devices and compounds used in delivery and release. Letter grading.
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6.00 Credits
Lecture, five hours. Requisites: Chemistry 110A, 153A, 153B, 153C, 156. Chemical and physical properties of proteins and nucleic acids. Biosynthesis, structure, and function of proteins, nucleic acids, and multicomponent complexes; protein and nucleic acid enzymology and gene expression. Structure, cloning, and analysis of DNA; biosynthesis and processing of RNA; biosynthesis, purification, structure, and analysis of proteins; correlation of structure and biological properties. Short computer module to teach aspects of protein structure. Genetic, molecular genetic, genomic, and proteomic approaches in bacteria and yeast. Concurrently scheduled with course CM253. Letter grading.
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6.00 Credits
Lecture, five hours. Requisites: Chemistry 153A, 153B, 153C. Recommended: course CM153G. Fundamental principles and experimental approaches in four areas of cell biology: cell cycle regulation, signal transduction, intracellular protein transport, and structure and function of cytoskeleton, including cell-cell and cell-substrate interactions. Genetics and molecular genetics of Drosophila and mammals. Concurrently scheduled with course CM267A. Letter grading.
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2.00 Credits
Seminar, two hours. Designed for undergraduate fellows in Howard Hughes Undergraduate Research Program. Presentation of weekly seminars on research literature in fields of biochemistry and molecular biology. Reading, discussion, and development of culminating project. May be repeated for credit. P/NP grading.
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