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Course Criteria
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4.00 Credits
This course will introduce students to key concepts in genetic analysis, eukaryotic cell biology, and state-of-the-art approaches in genomic medicine. Lectures will highlight basic knowledge of cellular processes with the basis for human diseases, particularly cancer. Prerequisite courses will have introduced students to the concepts of cells, the central dogma of molecular biology, and gene regulation. Emphasis in this course will be on eukaryotic cell processes, including cellular organization, dynamics, and signaling.
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4.00 Credits
Molecular biology of prokaryotic and eukaryotic cells and their viruses. Mechanisms of DNA replication, transcription, translation. Structure of genes and chromosomes. Regulation of gene expression. Biochemical processes and principles in membrane structure and function, intracellular trafficking and subcellular compartmentation, cytoskeletal architecture, nucleocytoplasmic transport, signal transduction mechanisms, and cell cycle control.
Description: Experimental techniques of biochemistry and molecular biology, designed to accompany the lectures in 100B and 110.
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4.00 Credits
Experimental techniques of biochemistry and molecular biology, designed to accompany the lectures in 100B and 110.
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1.00 Credits
Mutational cancer theories do not explain why cancers: 1) have clonal individual karyotypes; 2) have polygenic transcriptomes and phenotypes; 3) have flexible karyotypes, which evolve progressive malignancy and drug resistance, but maintain autonomy and even immortality; and 4) Why carcinogens induce cancer only after conspicuously long latent periods of years to decades. To answer these questions, this course tests a new karyotypic theory, which postulates that cancers evolve much like new species.
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4.00 Credits
The course is designed for students interested in learning about the molecular and cell biology of cancer and how this knowledge is being applied to the prevention, diagnosis and therapy of cancer. Topics covered include tumor pathology and epidemiology; tumor viruses and oncogenes; intracellular signaling; tumor suppressors; multi-step carcinogenesis and tumor progression; genetic instability in cancer; tumor-host interactions; invasion and metastasis; tumor immunology; cancer therapy.
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4.00 Credits
Experimental analyses of central problems in cell biology and physiology using modern techniques, including DNA cloning and protein biochemistry, fluorescence microscopy of the cytoskeleton and organelles, DNA transfection and cell cycle analysis of cultured mammalian cells, RNA interference and drug treatments to analyze ion channel function in cell contractility and intracellular signaling, and somatosensation.
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3.00 Credits
Molecular mechanisms by which hormones elicit specific responses and regulate gene expression; hormone-receptor interaction; synthesis, transport and targeting of hormones, growth factors and receptors.
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4.00 Credits
Principles of mammalian (primarily human) physiology emphasizing physical, chemical, molecular and cellular bases of functional biology. The following topics will be covered: cellular and membrane ion and nonelectrolyte transport; cell and endocrine regulation; autonomic nervous system regulation; skeletal, smooth and cardiac muscle; cardiovascular physiology; respiration; renal physiology; gastrointestinal physiology. Discussion section led by Graduate Student Instructor will review material covered in lecture.
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4.00 Credits
In-depth introduction to genetics, including mechanisms of inheritance; gene transmission and recombination; transposable DNA elements; gene structure, function, and regulation; and developmental genetics. Some exams may be given in the evening.
Description: Experimental techniques in classical and molecular genetics.
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3.00 Credits
This course is intended for upper-division undergraduates seeking an interactive course based on modern concepts in evolution and comparative genomics. The course will emphasize the contribution of molecular evolution to a series of seminal events in life's history: origin of life; origin of cells; origin of eukaryotes; origin of multicellularity; evolution of animal development; human origins.
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