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Course Criteria
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3.00 - 4.00 Credits
Description: Course covers gene delivery systems (viral and non-viral), applications of gene therapy in disease states such as monogenic deficiencies, cancer and infectious diseases. Immune responses to cancer gene therapy and molecular engineering of biologically active molecules will be emphasized. Grading: Regular grades are awarded for this course: A B C D E. Prerequisite(s): IMB 519; undergraduate immunology and basic cell and molecular biology. Typical structure: 1 hour discussion, 3 hours lecture. Identical to: IMB 510; IMB is home department. Usually offered: Fall.
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3.00 - 4.00 Credits
Description: Biochemical, structural, and functional changes in cells, tissues, and organs, which cause and are caused by diseases. For graduate students training for a career in biomedical research. Grading: Regular grades are awarded for this course: A B C D E. Prerequisite(s): open to all graduate students. Typical structure: 3 hours lecture, 3 hours laboratory. Identical to: PATH 515; PATH is home department. Usually offered: Spring.
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3.00 Credits
Description: [Taught alternate years beginning Spring 2005]. The course will be coordinated through the Medicinal Chemistry Division of Pharmacology & Toxicology and will be Team Taught. Each semester four to five topics will be chosen for which the core areas of (chemistry, biochemistry, and medicinal chemistry) have been brought to bear on a specific biological question. Faculty, from the core areas, will lecture on each topic and lead discussions. Students will present material and lead discussions. Grading: Regular grades are awarded for this course: A B C D E. Identical to: PHSC 530; PHSC is home department. Usually offered: Spring.
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2.00 - 3.00 Credits
Description: Principles of absorption, distribution and excretion of drugs, with emphasis on mechanisms of drug metabolism. Grading: Regular grades are awarded for this course: A B C D E. Prerequisite(s): PCOL 602A. Identical to: PCOL 550; PCOL is home department. Usually offered: Spring.
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3.00 Credits
Description: Physical and chemical carcinogenesis. Special emphasis will be upon molecular aspects of the interaction of the carcinogenic agents with mammalian cells and the subsequent mutagenic and metabolic consequences of such interactions. The topics of oncogene activation and tumor suppressor gene inactivation induced by carcinogens during multi-stage carcinogenesis will be emphasized. The molecular biology techniques used in the study of carcinogenesis will also be covered. Grading: Regular grades are awarded for this course: A B C D E. Prerequisite(s): consent of department. Identical to: IMB 551, RONC 551. Usually offered: Fall.
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3.00 Credits
Description: Fundamental biological aspects of physical, chemical and biological therapies for cancer. Grading: Regular grades are awarded for this course: A B C D E. Identical to: CBA 555, IMB 555, MEDI 555, RONC 555. Usually offered: Spring.
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2.00 - 3.00 Credits
Description: Students will learn about the most common types of cancer and the four major clinical disciplines that are primarily responsible for diagnosing and treating patients with cancer. The course will be focused around a series of clinical experiences in which individual or small groups of students will observe a clinician in the practice of pathology, radiation oncology, medical oncology, and surgical oncology focused on one of the four major U.S. cancers, breast, colorectal, prostate, and lung cancer. Students will meet for one hour per week (12 weeks) with the course coordinator(s) and clinical faculty for didactic instruction on common types of cancer, lectures by clinicians in the major clinical disciplines, discussion of clinical observations and experiences, and to facilitate the scheduling of the clinical experiences. Students will be responsible for arranging a total of 12 hours of Clinical Experience Assignments with the assistance of the course coordinators, consisting of 8 hours of core assignments (4 assignments, 2 hours each) and 4 hours of elective assignments (1 2 hours each). Students will select from a variety of elective clinical experience assignments, observe a multidisciplinary case discussion conference in the major clinical subspecialties on a monthly basis, and learn about therapeutic development in cancer. Grading: Regular grades are awarded for this course: A B C D E. Usually offered: Spring.
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3.00 Credits
Description: The immunological mechanisms involved in host responses to tumors, with emphasis on the delineation of cellular interactions between immune cells and tumor cells that may result in tumor progression or rejection. Grading: Regular grades are awarded for this course: A B C D E. Identical to: IMB 562; IMB is home department. Usually offered: Fall.
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3.00 Credits
Description: Advanced treatment of the biochemistry and molecular biology of disease, considering both genomic and environmental factors. Grading: Regular grades are awarded for this course: A B C D E. Prerequisite(s): BIOC 462A, BIOC 462B, or consent of instructor. Identical to: BIOC 578; BIOC is home department. Usually offered: Spring.
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3.00 Credits
Description: Understanding of correlations of molecular biology/chromosomal change in human cancer and the role of genetic change in progression and metastasis of cancer. Grading: Regular grades are awarded for this course: A B C D E. Prerequisite(s): ECOL 320, MCB 320. May be repeated: for credit 1 time (maximum 2 enrollments). Identical to: GENE 589, IMB 589, MCB 589. Usually offered: Fall.
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