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Course Criteria
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3.00 Credits
(223) Second semester. Three credits. One class and two 3-hour laboratories. Prerequisite: BME 3301. Introduction to techniques used for industrial mass culture of prokaryotic and eukaryotic cells, and methods used to extract useful products from these cultures. Metabolic processes, energentics, growth kinetics and nutrition of microorganisms. Synthesis of cellular material and end products. Heat exchange, oxygen transfer, pH control, sterilization and design of fermentors. Culture of eukaryotic cell mass. Immobilized enzyme and cell reactors. Product recovery methods of precipitation centrifugation, extraction filtration and chromatography.
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4.00 Credits
(251) Second semester. Four credits. Prerequisite: BME 3100. This course and ECE 3101 may not be both taken for credit. A lecture and laboratory that covers Fourier analysis, LaPlace analysis and Z-transforms. Techniques for generating quantitative mathematical models of physiological control systems; the behavior of physiological control systems using both time and frequency domain methods.
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4.00 Credits
(252) First semester. Four credits. Prerequisite: BME 3400; ECE 2001W. A lecture and laboratory course that covers fundamentals of biomedical measurement and patient safety. Measurements of physical quantities by means of electronic instruments, mechanical devices and biochemical processes. Analysis of measurement systems using mathematical models. Methods of measuring signals in the presence of noise. Use of computers in measurement systems.
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4.00 Credits
(261W) First semester. Four credits. Prerequisite: BME 3100 and CE 2110; ENGL 1010 or 1011 or 3800. A lecture and laboratory course that covers mechanics of bone and soft tissues. Biosolids and biofluids. Simple and combined stress and strain, torsion and flexure. Tissue strength and constitutive equations. Fatigue and fracture resistance of bone. Synovial joint mechanics, friction and wear.
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4.00 Credits
(271) Second semester. Four credits. Prerequisite: MSE 2001 or 2101 and BME 3100. A lecture and laboratory course that introduces a series of implant materials including metals, ceramics, glass ceramics, polymers, and composites. These materials are compared with the natural materials, with consideration given to issues of mechanical properties, biocompatibility, degradation of materials by biological systems, and biological response to artificial materials. Particular attention is given to the materials for the total hip prosthesis, dental restoration, and implantable medical devices.
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3.00 Credits
(253) Semester by arrangement. Three credits. Prerequisite: BME 3400 or ECE 3111. Analysis of human physiological control systems and regulators through the use of mathematical models. Identification and linearization of system components. Systems interactions, stability, noise, and the relation of system malfunction to disease. The analysis and design of feedback systems to control physiological states through the automatic administration of drugs.
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3.00 Credits
(255) Either semester. Three credits. Prerequisite: BME 3500. Modeling, analysis, design, and operation of transducers, sensors, and electrodes, for physiological systems; operational and instrumentation amplifiers for bioelectric event signal conditioning, interfacing and processing; A/D converters and hardware and software principles as related to sampling, storing, processing, and display of biosignals and digital computers.
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3.00 Credits
(262) Either semester. Three credits. Prerequisite: BME 3600W. Mechanical behavior of biological solids. Applications of the theories of elasticity, viscoelasticity, and poroelasticity to bones, ligaments and tendons, skeletal muscle, and articular cartilage. Axial, bending, shearing and torsional loadings. Bone morphology and growth. Biphasic theory. Failure theories. Topics may be modified slightly to accommodate student interests.
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3.00 Credits
(273) Second semester. Three credits. Prerequisite: BME 3700. Not open to students who have passed BME 272. Offers opportunity to gain in-depth knowledge of a series of biomaterials for various applications. Topics include calcium phosphates and composites for hard tissue replacement, drug delivery systems, issues unique to the biomedical field, and regulations for new products and standards.
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3.00 Credits
(274) Second semester. Three credits. Prerequisite: BME 3700. Presents basic principles of biological, medical, and material science as applied to implantable medical devices, drug delivery systems and artificial organs.
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