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  • Bi 220: Genetic Dissection of Neural Circuit Function

    6.00 Credits
    California Institute of Technology

    This advanced course will discuss the emerging science of neural “circuit breaking” through the application of molecular genetic tools. These include optogenetic and pharmacogenetic manipulations of neuronal activity, genetically based tracing of neuronal connectivity, and genetically based indicators of neuronal activity. Both viral and transgenic approaches will be covered, and examples will be drawn from both the invertebrate and vertebrate literature. Interested students who have little or no familiarity with molecular biology will be supplied with the necessary background information. Lectures and student presentations from the current literature. Instructor: Anderson.
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  • Bi 221: Computational Neuroscience

    9.00 Credits
    California Institute of Technology

    Lecture and discussion aimed at understanding computational aspects of information processing within the nervous system. The course will emphasize single neurons and how their biophysical properties relate to neuronal coding, i.e., how information is actually represented in the brain at the level of action potentials. Topics include biophysics of single neurons, signal detection and signal reconstruction, information theory, population coding and temporal coding in sensory systems of invertebrates and in the primate cortex. Students are required to hand in three homework assignments, discuss one set of papers in class, and participate in the debates. Not offered 2012–13.
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  • Bi 227: Methods in Modern Microscopy

    12.00 Credits
    California Institute of Technology

    Discussion and laboratory-based course covering the practical use of the confocal microscope, with special attention to the dynamic analysis of living cells and embryos. Course will begin with basic optics, microscope design, Koehler illumination, and the principles of confocal microscopy. After introductory period, the course will consist of semi-independent weeklong modules organized around different imaging challenges. Early modules will focus on three-dimensional reconstruction of fixed cells and tissues, with particular attention being paid to accurately imaging very dim samples. Later modules will include time-lapse confocal analysis of living cells and embryos, including zebra fish, chicken, and embryos. Dynamic analysis will emphasize the use of fluorescent proteins. No prior experience with confocal microscopy will be assumed; however, a basic working knowledge of microscopes is highly recommended. Preference is given to graduate students who will be using confocal microscopy in their research. Instructor: Staff. Prerequisite:    Bi/BE 177 or a course in microscopy. Bi 177 may be taken concurrently with this course.
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  • Bi 23: Biology Tutorial

    3.00 - 6.00 Credits
    California Institute of Technology

    Small group study and discussion in depth of special areas or problems in biology, involving regular tutorial sections with instructors. Usually given winter and/or spring terms. To be arranged with instructors before registration. Graded pass/fail. Instructor: Huang.
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  • Bi 231: Advanced Topics in Biochemistry

    6.00 Credits
    California Institute of Technology

    Transcriptional regulation in eukaryotes. Topics: the subunit structure of eukaryotic RNA polymerases and their role in transcriptional reactions; the composition of eukaryotic promoters, including regulatory units; general and specific transcription factors; developmental regulatory circuits and factors; structural motifs involved in DNA binding and transcriptional initiation and control. Not offered 2012–13.
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  • Bi 24: Technical Communication for Biologists

    6.00 Credits
    California Institute of Technology

    This course offers instruction and practice in writing and speaking relevant to professional biologists working in research, teaching, and/or medical careers. Students may write a paper for a scientific journal, based on their previous research and mentored by a faculty member. Alternatively, students may produce a variety of brief writing assignments with a range of audiences and purposes. Oral presentations will be based on writing produced in the course, with feedback from instructors and peers. Not offered 2012–13.
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  • Bi 244: Paleobiology Seminar

    6.00 Credits
    California Institute of Technology

    Critical reviews and discussion of classic investigations and current research in paleoecology, evolution, and biogeochemistry. Instructor: Kirschvink.
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  • Bi 246: Molecular Geobiology Seminar

    6.00 Credits
    California Institute of Technology

    Critical reviews and discussion of classic papers and current research in microbiology and geomicrobiology. As the topics will vary from year to year, it may be taken multiple times. Given in alternate years; not offered 2012–13.
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  • Bi 247: Cerebral Cortex

    6.00 Credits
    California Institute of Technology

    A general survey of the structure and function of the cerebral cortex. Topics include cortical anatomy, functional localization, and newer computational approaches to understanding cortical processing operations. Motor cortex, sensory cortex (visual, auditory, and somatosensory cortex), association cortex, and limbic cortex. Emphasis is on using animal models to understand human cortical function and includes correlations between animal studies and human neuropsychological and functional imaging literature. Instructor: Andersen. Given in alternate years; offered 2012–13.
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  • Bi 250 a: Topics in Molecular and Cellular Biology

    9.00 Credits
    California Institute of Technology

    Lectures and discussion covering research methods, logic, techniques and strategies, fundamental and general principles of modern biology, and unsolved problems. Students will learn to critique papers on molecular biology, cell biology, and genetics. Instructor: Prober.
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