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Bi 191 ab: Biomolecular Computation
9.00 Credits
California Institute of Technology
This course investigates computation by molecular systems, emphasizing models of computation based on the underlying physics, chemistry, and organization of biological cells. We will explore programmability, complexity, simulation of and reasoning about abstract models of chemical reaction networks, molecular folding, molecular self-assembly, and molecular motors, with an emphasis on universal architectures for computation, control, and construction within molecular systems. If time permits, we will also discuss biological example systems such as signal transduction, genetic regulatory networks, and the cytoskeleton; physical limits of computation, reversibility, reliability, and the role of noise, DNA-based computers and DNA nanotechnology. Part a develops fundamental results; part b is a reading and research course: classic and current papers will be discussed, and students will do projects on current research topics. Instructor: Winfree.
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Bi 191 ab - Biomolecular Computation
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Bi 199: Introduction to MATLAB for Biologists
6.00 Credits
California Institute of Technology
This hands-on course provides an introduction to MATLAB’s structure and syntax, writing of functions and scripts, image analysis, and data visualization. Instructor: Kennedy.
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Bi 199 - Introduction to MATLAB for Biologists
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Bi 2: Current Research in Biology
3.00 Credits
California Institute of Technology
Current research in biology will be discussed, on the basis of reading assigned in advance of the discussions, with members of the divisional faculty. Graded pass/fail. Instructor: Elowitz.
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Bi 2 - Current Research in Biology
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Bi 202: Neurobiology of Disease
9.00 Credits
California Institute of Technology
This course will cover the cellular and molecular basis of diseases of the nervous system, as well as current and future therapeutic approaches. These diseases include disorders of abnormal protein structure (Alzheimer’s, Huntington’s, Parkinson’s, prion), autoimmunity (multiple sclerosis), developmental disorders of cognition and social communication (schizophrenia, autism, Fragile X, Rett syndrome), epilepsy, stroke and depression. Genetic and environmental etiologies will be explored, and animal models will be compared to the human condition. The role of the reward system in addiction will also be discussed. Instructor: Patterson. Given in alternate years; offered 2012–13.
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Bi 202 - Neurobiology of Disease
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Bi 204: Evolution of the Animal Body Plan
6.00 Credits
California Institute of Technology
Evolution of animal forms will be considered mechanistically in terms of change in the genomic regulatory programs underlying the developmental ontogeny of these forms, but within the framework provided by current concepts of animal phylogeny. Evolutionary mechanisms will be considered, as well, with respect to the real-time paleontological record and the changing conditions of Earth’s environment through geological time. Principles emerging from the system biology of regulatory evolution will be emphasized. Instructor: Davidson. Given in alternate years; offered 2012–13.
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Bi 204 - Evolution of the Animal Body Plan
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Bi 206: Biochemical and Genetic Methods in Biological Research
6.00 Credits
California Institute of Technology
This course will comprise in-depth discussions of selected methods in molecular biology and related fields. Given the enormous range of techniques available to a molecular biologist nowadays, the course will focus on a subset of these methods that includes recent and highly promising techniques, with an emphasis on their robustness and general applicability. Instructor: Varshavsky.
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Bi 206 - Biochemical and Genetic Methods in Biological Research
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Bi 214: Hematopoiesis: A Developmental System
6.00 Credits
California Institute of Technology
An advanced course with lectures and seminar presentations, based on reading from the current literature. The characteristics of blood cells offer unique insights into the molecular basis of lineage commitment and the mechanisms that control the production of diverse cell types from pluripotent precursors. The course will cover the nature of stem cells, the lineage relationships among differentiated cell types, the role of cytokines and cytokine receptors, apoptosis and lineage-specific proliferation, and how differentiation works at the level of gene regulation and regulatory networks. Roles of prominent regulatory molecules in hematopoietic development will be compared with their roles in other developmental systems. Emphasis will be on explanation of cellular and system-level phenomena in terms of molecular mechanisms. Instructor: Rothenberg. Given in alternate years; offered 2012–13.
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Bi 214 - Hematopoiesis: A Developmental System
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Bi 216: Behavior of Mammals
6.00 Credits
California Institute of Technology
A course of lectures, readings, and discussions focused on the genetic, physiological, and ecological bases of behavior in mammals. A basic knowledge of neuroanatomy and neurophysiology is desirable. Given in alternate years; not offered 2012–13.
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Bi 216 - Behavior of Mammals
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Bi 217: Central Mechanisms in Perception
6.00 Credits
California Institute of Technology
Reading and discussions of behavioral and electrophysiological studies of the systems for the processing of sensory information in the brain. Instructor: Allman. Given in alternate years; offered 2012–13.
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Bi 217 - Central Mechanisms in Perception
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Bi 22: Undergraduate Research
1.00 - 9.00 Credits
California Institute of Technology
Special problems involving laboratory research in biology; to be arranged with instructors before registration. Graded pass/fail. Instructor: Staff.
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Bi 22 - Undergraduate Research
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