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  • Bi 117: Developmental Biology

    9.00 Credits
    California Institute of Technology

    A survey of the development of multicellular organisms. Topics will include the beginning of a new organism (fertilization), the creation of multicellularity (cellularization, cleavage), reorganization into germ layers (gastrulation), induction of the nervous system (neurulation), and creation of specific organs (organogenesis). Emphasis will be placed on the molecular mechanisms underlying morphogenetic movements, differentiation, and interactions during development, covering both classical and modern approaches to studying these processes. Instructor: Bronner. Prerequisite:    Bi 8 and Bi 9.
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  • Bi 118: Morphogenesis of Developmental Systems

    6.00 Credits
    California Institute of Technology

    Lectures on and discussion of how cells, tissues, and organs take shape: the influence of force on cell shape change; cell migration including chemotaxis and collective cell movement; adhesion/deadhesion during migration; the relationship between cell migration and metastasis; and a review/overview of general signaling principles and embryonic development of invertebrate and vertebrate animals. Instructor: Stathopoulos. Given in alternate years; offered 2012-13. Prerequisite:    Bi 8 and Bi 9, and at least one of the following: Bi 117, Bi 122, Bi 129, Bi 145, or Bi 182 (or equivalents).
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  • Bi 120: The Neuronal Basis of Consciousness

    9.00 Credits
    California Institute of Technology

    What are the correlates of consciousness in the brain? The course provides a framework for beginning to address this question using a reductionist point of view. It focuses on the neurophysiology of the primate visual system, but also discusses alternative approaches more suitable for work with rodents. Topics to be covered include the anatomy and physiology of the primate’s visual system (striate and extrastriate cortical areas, dorsal/ventral distinction, visual-frontal connections), iconic and working memory, selective visual attention, visual illusions, clinical studies (neglect, blind sight, split-brain, agnosia), direct stimulation of the brain, delay and trace associative conditioning, conscious and unconscious olfactory processing, and philosophical approaches to consciousness. Not offered 2012–13.
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  • Bi 122: Genetics

    9.00 Credits
    California Institute of Technology

    Lecture and discussion course covering basic principles of genetics. Instructor: Hay.
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  • Bi 123: Genetics Laboratory

    12.00 Credits
    California Institute of Technology

    Laboratory exercises illustrating the principles of genetics, with emphasis on Mendelian inheritance in multicellular eukaryotes, including and Given in alternate years; not offered 2012–13.
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  • Bi 129: Biology of Cancer

    9.00 Credits
    California Institute of Technology

    The first part of the course will concern the basic biology of cancer, covering oncogenes, tumor suppressors, tumor cell biology, metastasis, tumor angiogenesis, and other topics. There will also be a section on cancer genetics, which will primarily be taught from primary literature and journal reviews. The last part of the course will concern treatments, including chemotherapy, anti-angiogenic therapy, and immunotherapy. Textbook: (2006) by Robert Weinberg Instructor: Zinn. Given in alternate years; offered 2012–13.
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  • Bi 13: In Search of Memory

    6.00 Credits
    California Institute of Technology

    An exploration of brain function based on weekly readings in an autobiographical account by a Nobel Prize willing neurobiologist. No lectures. Each week there will be reading from chapters of the book plus relevant research papers, discussing trail-blazing neuroscience experiments. Instructor: Pine.
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  • Bi 131: The Psychology of Learning and Motivation

    9.00 Credits
    California Institute of Technology

    This course will serve as an introduction to basic concepts, findings, and theory from the field of behavioral psychology, covering areas such as principles of classical conditioning, blocking and conditioned inhibition, models of classical conditioning, instrumental conditioning, reinforcement schedules, punishment and avoidance learning. The course will track the development of ideas from the beginnings of behavioral psychology in the early 20th century to contemporary learning theory. Not offered 2012–13.
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  • Bi 132: Biophysics of Macromolecules

    9.00 Credits
    California Institute of Technology

    Structural and functional aspects of nucleic acids and proteins, including hybridization; electrophoretic behavior of nucleic acids; principles and energetics of folding of polypeptide chains in proteins; allostery and cooperativity in protein action; enzyme kinetics and mechanisms; and methods of structure determination, such as X-ray diffraction and magnetic resonance. Structure and function of metalloenzymes. Instructors: Beauchamp, Cai.
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  • Bi 145: Tissue and Organ Physiology

    9.00 Credits
    California Institute of Technology

    Reviews of embryology, anatomy, and histology, as well as in-depth discussion of cellular physiology (from a control and digital logic perspective). Topics will include building from cell function to tissues, hematologic, connective tissue, musculoskeletal physiology, and integration of these tissue functions into the function of the cardiovascular system, in an organ-based fashion, with pulmonary, renal, gastrointestinal, hepatobiliary, neuroendocrine, and reproductive physiology. Specific topics in advanced physiology, including cardiovascular and pulmonary physiology, exercise, nutrition, congenital abnormalities, selected topics in pathophysiology. Instructor: Tydell. Prerequisite:    Bi 8, 9, 110, 117. Bi 110 may be taken concurrently.
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