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  • Bi 1: Principles of Biology

    9.00 Credits
    California Institute of Technology

    Advances in biotechnology have driven unprecedented integration across the hierarchy of biology, from molecules to ecosystems, as well as the integration of biology with other sciences, including geology, physics, chemistry and mathematics. The design of this biology course seeks to provide introductory students with a strong foundation built on a set of basic principles that will provide students with the intellectual tools for critical thinking in the discipline. Because the microbial world has been critical in all aspects of biology, from the environmental to human health, throughout the evolution of the biosphere, a microbiological perspective will form the nucleus around which each major topic will be developed. Specifically, we will discuss key concepts in cellular and molecular biology (e.g. cytoskeletal elements, transcription, translation), ecology, evolution, and metabolism (e.g. biosynthesis and energy generation) by providing examples from the microbial world. Instructor: Newman.
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  • Bi 1 x: The Great Ideas of Biology: An Introduction through Experimentation

    9.00 Credits
    California Institute of Technology

    Introduction to concepts and laboratory methods in biology. Molecular biology techniques and advanced microscopy will be combined to explore the great ideas of biology. This course is intended for nonbiology majors and will satisfy the freshman biology course requirement. Limited enrollment. Instructor: Phillips.
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  • Bi 10: Cell Biology Laboratory

    6.00 Credits
    California Institute of Technology

    Introduction to basic methods in cell and molecular biological research, including polymerase chain reaction, molecular cloning, expression and purification of recombinant fusion proteins in bacteria, enzymology, and gel electrophoresis of proteins and nucleic acids. Instructor: Deshaies.
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  • Bi 102 ab: Brains, Minds, and Society

    9.00 Credits
    California Institute of Technology

    Introduction to the computations made by the brain during economic and social decision making and their neural substrates. First quarter: Signal detection theory. Unconscious and conscious processing. Emotion and the somatic marker hypothesis. Perceptual decision making. Reinforcement learning. Goal and habit learning. Facial processing in social neuroscience. Second quarter: Optimal Bayesian decision making and prospect theory. Standard and behavioral game theory. Evolution and group decision making. Collective decision making by animals. Exploration. Risk learning. Probabilistic sophistication. Instructors: Adolphs, Bossaerts, Camerer, O’Doherty. Part b not offered 2012–13.
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  • Bi 107: Writing about Scientific Research

    9.00 Credits
    California Institute of Technology

    This will be a hands-on course in which students learn how to write a long essay or a book explaining complex scientific research. The course will focus on learning to write clearly and compellingly, to rewrite and edit, and, especially, to find one’s own writing voice. In the first part of the course, students will read, analyze, and critique published works, including some early drafts of well-known books. Together, we will study different writing styles; how chapters, articles, and books are structured; and basic narrative techniques and their execution. In the second part of the course students will select a cutting-edge scientific research topic to write about and produce a book chapter on that topic. Students’ works-in-progress will be analyzed each week in class. The finished chapters will be included in a manuscript for a book one might call The Caltech Student’s Guide to the Most Awesome Cutting Edge Science, 2012. Limited enrollment. Instructor: Mlodinow.
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  • Bi 110: Introduction to Biochemistry

    12.00 Credits
    California Institute of Technology

    Lectures and recitation introducing the molecular basis of life processes, with emphasis on the structure and function of proteins. Topics will include the derivation of protein structure from the information inherent in a genome, biological catalysis, the intermediary metabolism that provides energy to an organism, and the use of DNA manipulations, cloning, and expression of proteins in foreign hosts to study protein structure and function. Instructors: Richards, Biochemistry faculty.
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  • Bi 111: Biochemistry of Gene Expression

    12.00 Credits
    California Institute of Technology

    Lectures and recitation on the molecular basis of biological structure and function. Emphasizes the storage, transmission, and expression of genetic information in cells. Specific topics include DNA replication, recombination, repair and mutagenesis, transcription, RNA processing, and protein synthesis. Instructors: Campbell, Parker. Prerequisite:    Bi/Ch 110; Bi 8 and Bi 122 recommended.
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  • Bi 113: Biochemistry of the Cell

    12.00 Credits
    California Institute of Technology

    Lectures and recitation on the biochemistry of basic cellular processes in the cytosol and at the cell surface, with emphasis on signal transduction, membrane trafficking, and control of cell division. Specific topics include cell-cell signaling, control of gene expression by cell surface molecules, tumorigenesis, endocytosis, exocytosis, viral entry, and cell cycle regulation. Instructors: Chan, Hoelz. Prerequisite:    Bi/Ch 110; Bi 9 recommended.
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  • Bi 114: Immunology

    9.00 Credits
    California Institute of Technology

    The course will cover the molecular and cellular mechanisms that mediate recognition and response in the mammalian immune system. Topics include cellular and humoral immunity, the structural basis of immune recognition, antigen presentation and processing, developmental regulation of gene rearrangement, biochemistry of lymphocyte activation, lymphokines and the regulation of cellular responses, T and B cell development, and mechanisms of tolerance. Instructor: Mazmanian. Prerequisite:    Bi 8, Bi 9, Bi 122 or equivalent, and Bi/Ch 110 recommended.
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  • Bi 115: Attack and Repulsion: Viruses and their Hosts

    9.00 Credits
    California Institute of Technology

    The course will introduce the chemistry and biology of viruses, emphasizing their diverse replication strategies. It will then focus on mechanisms used by viruses to multiply in the face of host defenses. It will also discuss cancer-inducing viruses. The course will mainly consider mammalian viruses but will also discuss aspects of plant and bacterial viruses. Given in alternate years; not offered 2012–13.
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