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  • BE 177: Principles of Modern Microscopy

    9.00 Credits
    California Institute of Technology

    Lectures and discussions on the underlying principles behind digital, video, differential interference contrast, phase contrast, confocal, and two-photon microscopy. The course will begin with basic geometric optics, characteristics of lenses and microscopes, and principles of accurate imaging. Specific attention will be given to how different imaging elements such as filters, detectors, and objective lenses contribute to the final image. Course work will include critical evaluation of published images and design strategies for simple optical systems. Emphasis in the second half of the course will be placed on the analysis and presentation of two- and three-dimensional images. No prior knowledge of microscopy will be assumed. Instructor: Staff.
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  • BE 181: Biological Interfaces, Transduction, and Sensing

    9.00 Credits
    California Institute of Technology

    Basic physics and chemical physics of interfaces between the fundamental realm of biology—molecules and cells—and the physical world. The course centers on processes that are essential for transduction to energy domains in which modern sensors operate. Information transfer from the biological realm to optical, electronic, and mechanical domains will be considered. Particular attention will be paid to both the sensitivity and the kinetics of transduction processes, and to how fluctuations affect and ultimately impose fundamental limits on such interactions. Instructor: Roukes. Prerequisite:    APh 105, Ph129 or equivalent (students without a background in statistical physics are still encouraged to take the course—additional tutorial sessions will be arranged as needed).
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  • BE 185: MEMS Technology and Devices

    9.00 Credits
    California Institute of Technology

    Micro-electro-mechanical systems (MEMS) have been broadly used for biochemical, medical, RF, and lab-on-a-chip applications. This course will cover both MEMS technologies (e.g., micro- and nanofabrication) and devices. For example, MEMS technologies include anisotropic wet etching, RIE, deep RIE, micro/nano molding and advanced packaging. This course will also cover various MEMS devices used in microsensors and actuators. Examples will include pressure sensors, accelerometers, gyros, FR filters, digital mirrors, microfluidics, micro total-analysis system, biomedical implants, etc. Instructor: Tai; offered 2012–13.
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  • BE 189 ab: Design and Construction of Biodevices

    12.00 Credits
    California Institute of Technology

    Part a, students will design and implement biosensing systems, including a pulse monitor, a pulse oximeter, and a real-time polymerase-chain-reaction incubator. Students will learn to program in LABVIEW. Part b is a student-initiated design project requiring instructor’s permission for enrollment. Enrollment is limited to 24 students. BE/EE 189 a is an option requirement; BE/EE 189 b is not. Instructor: Yang.
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  • BE 191 ab: Biomolecular Computation

    9.00 Credits
    California Institute of Technology

    This course investigates computation by molecular systems, emphasizing models of computation based on the underlying physics, chemistry, and organization of biological cells. We will explore programmability, complexity, simulation of and reasoning about abstract models of chemical reaction networks, molecular folding, molecular self-assembly, and molecular motors, with an emphasis on universal architectures for computation, control, and construction within molecular systems. If time permits, we will also discuss biological example systems such as signal transduction, genetic regulatory networks, and the cytoskeleton; physical limits of computation, reversibility, reliability, and the role of noise, DNA-based computers and DNA nanotechnology. Part a develops fundamental results; part b is a reading and research course: classic and current papers will be discussed, and students will do projects on current research topics. Instructor: Winfree.
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  • BE 200: Research in Bioengineering

    1.00 - 9.00 Credits
    California Institute of Technology

    By arrangement with members of the staff, properly qualified graduate students are directed in bioengineering research.
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  • BE 227: Methods in Modern Microscopy

    12.00 Credits
    California Institute of Technology

    Discussion and laboratory-based course covering the practical use of the confocal microscope, with special attention to the dynamic analysis of living cells and embryos. Course will begin with basic optics, microscope design, Koehler illumination, and the principles of confocal microscopy. After introductory period, the course will consist of semi-independent weeklong modules organized around different imaging challenges. Early modules will focus on three-dimensional reconstruction of fixed cells and tissues, with particular attention being paid to accurately imaging very dim samples. Later modules will include time-lapse confocal analysis of living cells and embryos, including zebra fish, chicken, and embryos. Dynamic analysis will emphasize the use of fluorescent proteins. No prior experience with confocal microscopy will be assumed; however, a basic working knowledge of microscopes is highly recommended. Preference is given to graduate students who will be using confocal microscopy in their research. Instructor: Staff.
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  • BE 240: Special Topics in Bioengineering

    1.00 - 9.00 Credits
    California Institute of Technology

    Topics relevant to the general educational goals of the bioengineering option. Graded pass/fail.
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  • BE 242: Biological Flows: Propulsion

    9.00 Credits
    California Institute of Technology

    Physical principles of unsteady fluid momentum transport: equations of motion, dimensional analysis, conservation laws. Unsteady vortex dynamics: vorticity generation and dynamics, vortex dipoles/rings, wake structure in unsteady flows. Life in moving fluids: unsteady drag, added-mass effects, virtual buoyancy, bounding and schooling, wake capture. Thrust generation by flapping, undulating, rowing, jetting. Low Reynolds number propulsion. Bioinspired design of propulsion devices. Not offered 2012–13.
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  • BE 243: Biological Flows: Transport and Circulatory Systems

    9.00 Credits
    California Institute of Technology

    Internal flows: steady and pulsatile blood flow in compliant vessels, internal flows in organisms. Fluid dynamics of the human circulatory system: heart, veins, and arteries (microcirculation). Mass and momentum transport across membranes and endothelial layers. Fluid mechanics of the respiratory system. Renal circulation and circulatory system. Biological pumps. Not offered 2012–13.
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