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Course Criteria
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4.00 Credits
ENG EC 401, ENG BE 401, or ENG EK 510 and elementary knowledge of atomic physics. Methods of obtaining useful images of the interior of the body using X-rays, ultrasound, and radionuclides. Image formation and display. Projection radiography. Radiation detectors. Conventional and computerized tomography. Nuclear imaging. Automating diagnosis and non-invasive testing. Radiation safety. 4 cr.
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4.00 Credits
will learn the practice and the underlying theory of imaging with a focus on state-of-the-art live cell microscopy. Students will have the opportunity to use laser scanning confocal as well as widefield and near-field imaging to address experimental questions related to ion fluxes in cells, protein dynamics and association, and will use phase and interference techniques to enhance the detection of low-contrast biological material. Exploration and discussion of detector technology, signals and signal processing, spectral separation methods, and physical mechanisms used to determine protein associations and protein diffusion in cells are integrated throughout the course. Students will be assigned weekly lab reports, a midterm and a final project consisting of a paper and an oral presentation on a current research topic involving optical microscopy. 4 cr.
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4.00 Credits
ENG EK 424 or ENG ME 309 and either ENG ME 304, ENG ME 422, ENG BE 420, ENG BE 436, or consent of instructor. The main goal of this course is to present a unified, mathematically rigorous approach to two classical branches of mechanics: the mechanics of fluids and the mechanics of solids. Topics will include kinematics, stress analysis, balance laws (mass, momentum, and energy), the entropy inequality, and constitutive equations in the framework of Cartesian vectors and tensors. Emphasis will be placed on mechanical principles that apply to all materials by using the unifying mathematical framework of Cartesian vectors and tensors. Illustrative examples from biology and physiology will be used to describe basic concepts in continuum mechanics. The course will end at the point from which specialized courses devoted to problems in fluid mechanics (e.g., biotransport) and solid mechanics (e.g., cellular biomechanics) could logically proceed; students may not receive credit for both. 4 cr.
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4.00 Credits
the chemistry and engineering skills needed to solve challenges in the biomaterials and tissue engineering area, concentrating on the fundamental principles in biomedical engineering, material science, and chemistry. Covers the structure and properties of hard materials (ceramics and metals) and soft materials (polymers and hydrogels). Includes the biological response to materials such as cell-surface interactions and inflammation. (Meets with BE 726 lectures.) 4 cr.
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4.00 Credits
the chemistry and engineering skills needed to solve challenges in the biomaterials and tissue engineering area, concentrating on material properties, mechanics, and specific research topics. Covers the rheological properties of polymers and gels as well as fatigue and fracture of materials. Research topics such as tissue engineering, polymer chemistry, drug delivery, and micro-nano biosystems. (Meets with BE 727 lectures.) 4 cr.
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4.00 Credits
ENG BE 420 and ENG EK 424. An introductory course emphasizing those rheological properties (such as elasticity, viscoelasticity, poroelasticity, plasticity, and viscoplasticity) that often characterize solid biological tissues. 4 cr.
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4.00 Credits
ENG BE 209, ENG ME 305, ENG EK 424, and ENG BE 436 or equivalent. The physical and chemical basis for the mechanical properties and activities of living cells considered from an engineering perspective. The instructional approach emphasizes in-depth study of a limited number of cases and relies heavily on selected readings from the literature. Topics studied include cell adhesion and elasticity of red cells as well as phenomena in which active motility is involved (e.g., the first cleavage division of the sea urchin egg, the contraction of skeletal muscle, the crawling motility of fibroblastic cells, and the beating of flagella). Lectures and assignments emphasize the role of quantitative theory and mathematical models in elucidating the molecular basis of physiological observations in these diverse areas. 4 cr.
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3.00 Credits
graduate standing or permission of instructor; grad prereq: ENG BE 436 and ENG EK 424. Focuses on fundamental micro- and nanofabrication approaches to engineer the cellular and subcellular environment. The course covers applications of these technologies in the biomedical and biochemical fields, ranging from microanalytical systems to implantable drug delivery microsystems. 4 cr.
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4.00 Credits
CAS PY 212, CAS CH 131, or CAS CH 102. Provides an introduction to the molecular building blocks and the structure of three major components of the living cells: the nucleic acids, the phospholipids membrane, and the proteins. The nucleic acids, DNA and RNA, linear information storing structure as well as their three-dimensional structure are covered in relationship to their function. This includes an introduction to information and coding theory. The analysis tools used in pattern identification representation and functional association are introduced and used to discuss the patterns characteristic of DNA and protein structure and biochemical function. The problems and current approaches to predicting protein structure including those using homology, energy minimization, and modeling are introduced. The future implications of our expanding biomolecular knowledge and of rational drug design are also discussed. 4 cr.
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4.00 Credits
ENG BE 209 and ENG BE 200, or equivalent. Fundamental concepts from molecular biology and molecular genetics are presented. Biological inferences are made from DNA and protein sequence data using mathematical and computer science techniques. Pairwise sequence comparative analyses and homolog identification are studied in detail. The dynamic programming algorithm is extended to deal with more general cases and is applied to RNA structure prediction. Additional topics include: multiple sequence alignment and conserved sequence pattern recognition methods, phylogenetic tree reconstruction to study molecular evolution, methods of identifying coding regions in genomic data, algorithms to solve the fragment assembly problem of DNA sequencing, techniques for physical mapping, mathematical models and computations alogrithms for genetic regulation. An introduction to protein 3-dimensional structure predictions is also given. 4 cr.
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