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Course Criteria
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2.00 Credits
limited to biomedical engieering majors with senior standing. A combined academic- and industry-taught course educating students on project definition and on the design, development, and technology transfer of potential biomedical products in the context of the student's major capstone project. Students will learn from faculty and industry lecturers the best practices for medical device development, including: product development via design and process control, intellectual property and innovation in biomedical engineering including patents, and clinical regulatory issues including clinical trial design. School of Management faculty will emphasize marketing, technology transfer, and entrepreneurship for bioengineering products. Case study examples will be provided. This course is a required corequisite to ENG BE 465 in the fall semester for BME seniors. 2 cr.
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2.00 Credits
ENG BE 401. Laboratory course designed to develop experimental and modeling skills. Simulation of physical and physiological systems, experimental determination of transfer functions, filtering properties of systems, transducer instrumentation, muscle dynamics, and spectral analysis. Emphasis is on comparison of experimental data with theoretical expectation. 2 cr.
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2.00 Credits
ENG BE 402 and ENG BE 436. Laboratory course designed to develop experimental and modeling skills. Simulation of physical and physiological systems, experimental determination of control systems behavior, transducer instrumentation, and fluid dynamics. 2 cr.
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3.00 Credits
engineering graduate student standing or permission of instructor; others by permission of instructor; specific prerequisites vary according to topic. Coverage of a specific topic in biomedical engineering. One topic covered in depth each semester offered. Subject matter varies from year to year. 4 cr.
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4.00 Credits
ENG EK 424 or equivalent, graduate standing; undergraduates must have stamped approval. Provides engineering perspectives on the building blocks of living cells and materials for biotechnology. Focuses on origins and synthesis in life and the laboratory, including biological pathways for sythesis of DNA, RNA, and proteins; transduction, transmission, storage, and retrieval of biological information by macromoleclues; polyerase chain reaction, restriction enzymes, DNA sequencing; energetics of protein folding and trafficking; mechanisms of enzymatic catalysts and receptor-ligand binding; cooperative proteins, multi-protein complexes, and control of metabolic pathways; generation, storage, transmission, and release of biomolecular energy; and methods for study and manipulation of molecules which will include isolation, purification, detection, chemical characterization, imaging, and visualization of structure. 4 cr.
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3.00 Credits
prereq: ENG BE 505. Building on the engineering perspective of molecular-cell biology presented in ENG BE 505, the objective of this course is to provide a basic understanding of the physical chemistry of molecular structures important in living cells and in technological applications. Topics include: noncovalent interactions of biomolecules in water, thermodynamics of solutions and phase mixtures; nonequilibrium kinetics; polymer physics and elasticity; lipid self-assembly and interfacial thermodynamics; biomembranes; adhesion and molecular bonding; chemical grafting and surface analysis. 4 cr.
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4.00 Credits
ENG BE 401 and graduate standing; seniors with consent of instructor. Coreq: ENG BE 436. The quantitative physiological aspects of the respiratory and cardiovascular systems are studied. Classical models of these systems are considered including lumped element models, branching tree structures, and distributed parameter models to predict wave propagation in compliant walled tubes filled with compressible or incompressible fluids. Extensive computer models are developed to simulate the behavior of these systems in the frequency and time domains. Includes lab. 4 cr.
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4.00 Credits
CAS BI 315, ENG BE 200, and ENG BE 401 or permission of instructor. Introduction to the anatomy, acoustics, and physiology of the mammalian auditory pathways from a systems prospective including implications for hearing aid and prosthetic design. Topics include measuring sound and microscopic motion, head-related transfer function, middle ear and cochlear mechanics, hair cell transduction, binaural processing in the brainstem and midbrain, auditory thalamic and cortical structure and function. 4 cr.
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3.00 Credits
ENG EC 412 and ENG BE 402; grad prereq: ENG EC 412 and ENG BE 402. Physiological signals, origin of biopotentials (ECG, EMG, EEG), biomedical transducers, and electrodes. Biomedical signal detection, amplifications, and filtering. Analog front-ends of biomedical instruments. Electrical safety in medical environment. Laboratory experiments supplement lectures. 4 cr.
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4.00 Credits
ENG BE 511, ENG EC 311, and ENG EC 412 or equivalent. An introduction to techniques for the design of biomedical instrumentation including sensors and their associated electronics. Mathematical models for a wide variety of sensors ranging from resistive sensors to biosensors are reviewed along with the resulting implications for the design of signal-conditioning electronics. A case-study approach is used in which specific sensor systems are evaluated for sensitivity, selectivity, dynamic range, response time, and reproducibility. Includes lab. 4 cr.
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