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Course Criteria
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3.00 Credits
PQ: Completion of the general education requirement in the biological sciences. This course meets one of the requirements of the microbiology specialization. This lecture/discussion course involves a comprehensive analysis of bacterial pathogens, the diseases that they cause, and the molecular mechanisms involved during pathogenesis. Students discuss recent original experimental work in the field of bacterial pathogenesis. J. Martinez. Spring.
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3.00 Credits
PQ: BIOS 20200. The subject matter of this course considers the wide variety of intracellular mechanisms that, when activated, change cell behavior. We cover aspects of intracellular signaling, the latter including detailed discussions of receptors, G-proteins, cyclic nucleotides, calcium and calcium-binding proteins, phosphoinositides, protein kinases, and phosphatases. M. Brady, C. Palfrey, M. Roe, J. Sun, R. Cohen. Autumn.
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3.00 Credits
PQ: A Fundamentals Sequence (BIOS 20180s or 20190s, or AP 5 sequence). Endocrinology is the study of hormones, which are chemical messengers released by tissues that regulate the activity of other cells in the body. This course covers the classical hormone systems, including hormones regulating metabolism, energy mobilization and storage, calcium and phosphate metabolism, reproduction, growth, "fight or flight," and circadian rhythms. We focus on historical perspective, the mechanisms of action, homeostatic regulation, and relevant human diseases for each system . M. Brady, R. Cohen. Winter.
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3.00 Credits
A Fundamentals Sequence (BIOS 20180s or 20190s, or AP 5 sequence) and BIOS 25227 recommended but not required. This course is a modern overview of the patho-physiologic, genetic, and molecular basis of human diseases with nutritional perspectives. We discuss human diseases (e.g., hypertension, cardiovascular diseases, obesity, diabetes, osteoporosis, alopecia). Y. C. Li, M. Musch. Spring.
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3.00 Credits
PQ: Completion of the general education requirement in the biological sciences. Not open to students specializing in microbiology or immunology. Approximately 25 percent of annual deaths in the world result from infectious diseases. Pathogens and their hosts are involved in a constant battle, leading to the recent emergence and re-emergence of deadly infections. This course explores the interplay between pathogen's strategies and the host' s immune system. AIDS, tuberculosis, the flu, and the bubonic plaque are among some of the diseases covered . B. Fineschi, I. Pavlova. Spring.
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3.00 Credits
PQ: BIOS 20180s or 20190s, 25206, and consent of instructor. Prior knowledge of microbiology (e.g., BIOS 25206) will be advantageous. This comprehensivesurvey course presents an integrated and detailed coverage of the tactics and logistics of innate and adaptive immune phenomena and conveys the elegance and complexity of the biological solutions evolved by multicellular organisms in their ongoing fights against the anti-immunology strategies of infectious agents. J. Quintans. Autumn.
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3.00 Credits
PQ: Consent of instructor. Five examples of diseases are selected each year among the following categories: autoimmune diseases, inflammatory bowel diseases, infection immunity, immunodeficiencies and gene therapy, and transplantation and tumor immunology. Each disease is studied in depth with general lectures that include, where applicable, histological analysis of diseased tissue samples and discussions of primary research papers on experimental disease models. Special emphasis is placed on understanding immunopathology within the framework of general immunological concepts and on experimental approaches to the study of immunopathological models. B. Jabri. Winter.
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3.00 Credits
PQ: BIOS 25206 and BIOS 25256. This course explores the basic principals of host defense against pathogens and pathogens' strategies to overcome host immune mechanisms. We address evolutionary aspects of innate and adaptive immune responses, while also studying specific examples of viral and bacterial interactions with their hosts. The reviews of relevant immunological mechanisms necessary for appreciation of host/pathogen interactions are incorporated in the studies of specific cases. A. Chervonsky. Autumn.
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3.00 Credits
PQ: BIOS 20200 or 25256, or consent of instructor. This discussion-oriented course examines the molecular principles of immune recognition. We explore the roles of protein modification, protein-protein and protein-DNA interactions in the discrimination between self and non-self, and study the molecular fundamentals of cell stimulation and signaling. Primary literature focused on molecular research of the immune system is integrated with lectures on commonly used biochemical, structural and immunological techniques used in the research papers examined. E. Adams. Spring.
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3.00 Credits
PQ: Completion of the general education requirement in the biological sciences and third- or fourth-year standing. This class on animal viruses considers the major families of the viral kingdom with an emphasis on the molecular aspects of genome expression and virus-host interactions. Our goal is to provide students with solid appreciation of basic knowledge, as well as instruction on the frontiers of virus research. T. Golovkina, B. Roizman, E. Pilipenko. Spring.
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