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Course Criteria
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3.00 Credits
PQ: CHEM 22000-22100-22200 or BIOS 20200 required; prior course in neurobiology or physiology recommended. This course examines the biology of pain and the mechanisms by which anesthetics alter the perception of pain. The approach is to examine the anatomy of pain pathways both centrally and peripherally, and to define electrophysiological, biophysical, and biochemical explanations underlying the action of general and local anesthetics. We discuss the role of opiates and enkephalins. Central theories of anesthesia, including the relevance of sleep proteins, are also examined. J. Moss. Winter.
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3.00 Credits
PQ: BIOS 20200 and 24236 or 24204, or consent of instructor. This lecture/seminar course explores the application of modern cellular and molecular techniques to clarify basic questions in neurobiology. Topics include mechanisms of synaptic transmission, protein trafficking, exo- and endo-cytosis, and development and mechanisms of neurological diseases. S. Sisodia. Spring.
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3.00 Credits
PQ: Prior college-level course in calculus required; some background in neurobiology and concurrent registration in BIOS 29405 recommended. This course briefly reviews the historical development of computational neuroscience and discusses the functional properties of individual neurons. The electrotonic structure of neurons, functional properties of synapses, and voltage-gated ion channels are discussed. P. Ulinski, Staff. Autumn. L.
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3.00 Credits
PQ: BIOS 24221 required; concurrent registration in BIOS 29406 recommended. This course considers computational approaches to vision. We cover the basic anatomy and physiology of the retina and central visual pathways, emphasizing computational approaches based on control theory, linear and nonlinear systems theory, and information theory. Winter. L.
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3.00 Credits
PQ: BIOS 24222. This course is concerned with the relationship of the nervous system to higher order behaviors (e.g., perception, action, attention, learning, memory). Psychophysical, functional imaging, and electrophysiological methods are introduced. Mathematical and statistical methods (e.g., neural networks, information theory, pattern recognition for studying neural encoding in individual neurons and populations of neurons) are discussed. Weekly lab sections allow students to program cognitive neuroscientific experiments and simulations. N. Hatsopoulos. Spring. L.
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3.00 Credits
PQ: NURB 31800 or BIOS 24203. This seminar course is devoted to basic clinical and pathological features and pathogenic mechanisms of neurological diseases. The first semester is devoted to a broad set of disorders ranging from developmental to acquired disorders of the central and peripheral nervous system. Weekly seminars are given by experts in the clinical and scientific aspects of the disease under discussion. For each lecture, students are given a brief description of clinical and pathological features of a given set of neurological diseases followed by a more detailed description of the current status of knowledge of several of the prototypic pathogenic mechanisms. C. Gomez, Staff. Winter.
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3.00 Credits
PQ: BIOS 24246. This seminar course is devoted to understanding pathogenic mechanisms of neuronal death, neurodegenerative disease, and neuronal repair. Weekly seminars are given by experts in the basic and clinical aspects of neurodegenerative diseases. For each lecture, students are provided with a brief description of clinical and pathological features of a given set or mechanistic category of neurodegenerative diseases that is followed by a more detailed description of the current status of knowledge of several of the prototypical pathogenic mechanisms. C. Gomez, Staff. Spring.
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3.00 Credits
PQ: BIOS 20180s or 20190s, or consent of instructor. This course focuses on several aspects of the molecular and cellular biology of human reproduction. We also discuss the basis of chemical/viral carcinogenesis and the progression, treatment, and prevention of cancer. The role of steroid hormones and their receptors in the control of growth, development, and specialized cell function is discussed in the context of normal and abnormal gene expression in human development and disease. Key historical events, research approaches, utilization of knowledge, recent advances in drug design and herbal medicines, and philosophies of scientific research are also covered. G. Greene. Spring.
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3.00 Credits
PQ: BIOS 20181, 20191, or 20239/20234; or consent of instructor. This course introduces the use of animals in biomedical research for the purposes of understanding, treating, and curing human disease. Particular emphasis is placed on rodent models in the context of genetic, molecular, and immunologic manipulations, as well as on the use of large animal surgical models. University veterinarians also provide information regarding humane animal care. C. L. Wardrip, B. Theriault. Spring.
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3.00 Credits
This course meets one of the requirements of the microbiology specialization. BIOS 25256). This course introduces bacterial diversity, physiology, ultra-structure, envelope assembly, metabolism, and genetics. In the discussion section, students review recent original experimental work in the field of bacterial physiology. D. Missiakas. Autumn.
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