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Course Criteria
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3.00 Credits
PQ: General chemistry, organic chemistry, and BIOS 20200. This course is devoted to RNA biochemistry and molecular biology and to RNA-protein interactions with special emphasis on ribosome structure and protein biosynthesis. Topics include the biochemistry of protein synthesis (i.e., the translation reactions such as initiation, elongation, and termination); tRNA structure and identity elements; rRNA (i.e., structure, processing, regulation of synthesis, function, and evolution); ribosomal proteins (i.e., structure, function, gene organization, regulation of synthesis); ribosome assembly; ribosome structure from immuno-electron microscopy, neutron scattering, and X-ray defraction; RNA (i.e., protein interactions including tRNA-aminoacyl-tRNA syntase, rRNA-ribosomal proteins, and other examples); and regulation and translation. I. Wool. Spring.
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3.00 Credits
PQ: BIOS 20200 and third- or fourth-year standing, or consent of instructor. This course emphasizes structure, mechanism, and kinetics of enzyme catalyzed reactions. We discuss protein sequence alignment, allostery, three-dimensional structure of proteins, steady-state kinetics, molecular dynamics, and molecular motors. A lab component consists of molecular graphics stereo viewing and analysis of enzyme-substrate complexes, and a discussion session is held each week for analysis of current research publications. M. Makinen. Spring.
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3.00 Credits
PQ: Consent of instructor. This course covers the properties of proteins, RNA, and DNA, as well as their interactions. We emphasize the interplay between structure, thermodynamics, folding, and function at the molecular level. Topics include cooperativity, linked equilibrium, hydrogen exchange, electrostatics, diffusion, and binding. T. Sosnick. Spring.
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3.00 Credits
PQ: A Fundamentals Sequence (BIOS 20180s or 20190s, or AP 5 sequence). This course provides a fundamental understanding of epithelial cell biology and pathobiology. Topics include the molecular mechanisms that drive polarization, apical and basolateral sorting, cell-cell and cell Cmatrix interactions, and disease states of epithelial cells (e.g., cancer, ischemia). K. Goss, K. Matlin, M. Zegers, M. ter Beest, J. Collier, P. Bouyer, E. Beyers. Spring.
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3.00 Credits
PQ: BIOS 20180s or 20190, or AP 5 sequence. This advanced-level course combines lectures, student presentations, and discussion sessions. It covers major topics on the developmental biology of embryos (e.g., formation of the germ line, gastrulation, segmentation, nervous system development, limb patterning, organogenesis). We make extensive use of the primary literature and emphasize experimental approaches (e.g., classical embryology, genetics, molecular genetics). K. Millen. Spring.
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3.00 Credits
PQ: Consent of instructor. This course covers advanced topics deaing with the biology and chemistry of the extracellular matrix, cell-matrix interactions, and current methodologies for engineering these interfaces. J. Collier, M. Mrksich, M. Gardel, K. Matlin. Spring.
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3.00 Credits
PQ: One year of calculus. Whether one is trying to read radio signals from faraway galaxies or to understand molecular structures, it is necessary to understand how to read, interpret, and process the data that contain the desired information. In this course, we learn how to process the information contained in images of molecules as seen in the electron microscope. We also deal with the principles involved in processing electron microscope images, including the underlying analytical methods and their computer implementation. R. Josephs. Spring.
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3.00 Credits
PQ: Completion of the general education requirement in the biological sciences. Prior chemistry and organismal biology courses. This course examines the physiologic, cellular, and biochemical functions of a series of organs and systems in their transition from fetal to newborn life in the human, and the implications of these changes for successful adaptation to independent life. Examples of failures of adaptation and disease states are presented and discussed. The organs and systems covered are brain, lung, heart, liver, immune system, blood-forming system, intestine, endocrine organs, and kidney. J. Marks. Winter.
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3.00 Credits
PQ: Fundamentals or AP 5 sequence. This course covers the structure and function of major anatomical systems of vertebrates. Lectures focus on vertebrate diversity, biomechanics, and behavior (from swimming and feeding to running, flying, seeing, and hearing). Labs involve detailed dissection of animals (muscles, organs, brains) and a focus on skull bones in a broad comparative context from fishes to frogs, turtles, alligators, mammals, birds, and humans. Field trip to Field Museum and visit to medical school lab for human dissection required. M. Westneat. Winter. L.
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3.00 Credits
PQ: Completion of the general education requirement for the biological sciences. Prior physics course required; prior chemistry and calculus courses recommended. This course introduces fluid mechanics and the interactions between biology and the physics of fluid flow (both air and water). Topics range from the fluid mechanics of blood flow to the physics (and biology) of flight in birds and insects. M. LaBarbera. Spring. Not offered 2009 C10; will be offered 201 0 -11. L.
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