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Course Criteria
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3.00 Credits
Chordate biology emphasizes the diversity and evolution of modern vertebrate life, drawing on a range of sources (from comparative anatomy and embryology to paleontology, biomechanics, and developmental genetics). Much of the work is lab-based, with ample opportunity to gain firsthand experience of the repeated themes of vertebrate bodyplans, as well as some of the extraordinary specializations manifest in living forms. The instructors, who are both actively engaged in vertebrate-centered research, take this course beyond the boundaries of standard textbook content. N. Shubin, M. Coates. Spring. L.
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3.00 Credits
PQ: Completion of BIOS 20182, 20192, or 20235. This course considers the different types of variation in the human genome and the tools that are used to characterize human genetic variation at the individual and population levels. We further explore how this variability is utilized to: (1) understand the molecular pathology of human disease, (2) aid in the diagnosis of human disease, (3) reconstruct human evolutionary origins and population history, and (4) unravel the evolutionary history of human genes and gene families. Throughout this course, we consider the social and ethical implications of human genetic research and medical applications. C. Ober, A. Di Rienzo. Winter.
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3.00 Credits
PQ: BIOS 20200 or equivalent. Third- or fourth-year standing. This course covers fundamental concepts in gene expression and RNA processing, and then focuses on ribosome dynamics, regulation of protein synthesis and turnover, chaperone and proteasome functions, RNA and protein shuttling in and out of the nucleus, trafficking to different cellular compartments, cytoskeleton structures, movement through the endoplasmic reticulum and golgi, mitochondrial and chloroplast biogenesis, signaling pathways from the cell surface to the nucleus, cell-cell interactions, and apoptosis. Experimental approaches in cell biology are emphasized. Students participate in discussions on specialized topics based on original research reviews. G. Lamppa. Autumn.
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3.00 Credits
PQ: Basic knowledge of genetics and biochemistry. Third- or fourth-year standing. This course covers the structure of genetic material, replication, recombination, and transcription and its regulation. Other topics include post-transcriptional regulation, chromatin and DNA repair (both after transcription), and protein synthesis. U. Storb, J. Staley. Winter.
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3.00 Credits
PQ: BIOS 21200, college-level statistics course, and consent of instructor. The goal of this course is to provide students with an understanding of genetic models for complex human disorders and quantitative traits. Students also learn how to conduct parametric and nonparametric linkage analyses, as well as linkage disequilibrium mapping using transmission/disequilibruim tests (TDT) and decay of haplotype sharing (DHS). N. Cox. Winter.
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3.00 Credits
PQ: BIOS 20182 or 20192. This course provides both an overview of developmental biology and in-depth coverage of selected topics, emphasizing the origins of classical concepts in the field as well as modern molecular and genetic approaches to the study of developmental processes. Subjects include cell fate determination, growth control, stem cells, signal transduction, neurogenesis, and cell polarity in developing systems. Underlying mechanisms are illuminated through discussion of key experiments. Discussion sections cover selected papers from the developmental biology literature, with emphasis on critical evaluation of experimental evidence. E. Ferguson, R. Fehon. Autumn.
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3.00 Credits
PQ: BIOS 20182 or 20192. This course deals with the molecular and cellular basis of genetic change. We discuss DNA repair functions, mutator loci, induced mutation, mechanisms of homologous recombination and gene conversion, site-specific recombination, transposable elements and DNA rearrangements, reverse transcription and retrotransposons, transposable vector systems for making transgenic organisms, and genetic engineering of DNA sequences in antibody formation. Discussion section required. J. Shapiro. Winter.
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3.00 Credits
PQ: BIOS 20182 or 20192. A small number of organisms have been chosen for extensive study by biologists. The popularity of these organisms derives largely from the fact that their genomes can be easily manipulated, allowing sophisticated characterization of biological function. This course covers modern methods for genetic analysis in budding yeast, Drosophila, C. elegans, Arabidopsis, and the mouse. Case studies demonstrate how particular strengths of each system have been exploited to understand such processes as genetic recombination, pattern formation, and epigenetic regulation of gene expression. D. Bishop, J. Malamy, E. Ferguson, A. Palmer. Autumn.
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3.00 Credits
PQ: BIOS 20180s or 20190s, or consent of instructor. Open only to students with advanced standing who are majoring in the biological sciences or preparing for the medical professions. This course deals with issues in genetics of variations within, as well as between, modern human populations. Normal genetic variations and the genetic basis of human diseases are explored with an emphasis at the molecular level. We stress understanding the fundamental concepts of genetics and evolution using mainly, but not exclusively, human studies as examples. Genome organization, genetic mapping, population genetic theories, and molecular evolution of humans are covered. C.-I. Wu, R. Hudson. Autumn.
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3.00 Credits
PQ: BIOS 20200. Required of students who are majoring in biological chemistry. This course examines a variety of biological problems from a chemical and structural perspective. Topics include macromolecular structure-function relationships, DNA and protein synthesis and repair, RNA folding and catalysis, molecular motors, nitrogen fixation; photosynthesis; and mechanisms of signal transduction. Computer graphics exercises and in-class journal clubs exercises complement the lecture topics. P. Rice, R. Keenan. Spring.
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