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Course Criteria
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3.00 Credits
This course is an introduction to molecular and cellular biology that emphasizes the unity of cellular processes amongst all living organisms. Topics are the structure, function, and synthesis of nucleic acids and protein; structure and function of cell organelles and extracellular matrices; energetics; cell cycle; cells in tissues and cell-signaling; altered cell functions in disease states; and some aspects of molecular evolution and the origin of cells. T. Martin, A. Imamoto, T. Christianson. Autumn. L.
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3.00 Credits
PQ: BIOS 20181. The goal of this course is to integrate recent developments in molecular genetics and the human genome project into the structure of classical genetics. Topics include Mendelian inheritance, linkage, tetrad analysis, DNA polymorphisms, human genome, chromosome aberrations and their molecular analysis, bacterial and virus genetics, regulatory mechanisms, DNA cloning, mechanism of mutation and recombination, and transposable elements. D. Bishop, J. Malamy, T. Christianson. Winter. L.
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3.00 Credits
PQ: BIOS 20181 and 20182. This course focuses on the physiological problems that animals (including humans) face in natural environments; solutions to these problems that the genome encodes; and the emergent physiological properties of the molecular, cellular, tissue, organ, and organismal levels of organization. Lectures and labs emphasize physiological reasoning, problem solving, and current research. D. McGehee, D. Hanck, M. Osadjan, C. Andrews. Spring. L.
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3.00 Credits
An overview of the diversity of living organisms, both prokaryotes and eukaryotes, is presented. We emphasize the major groups of organisms, their evolutionary histories and relationships, and the biological and evolutionary implications of the characteristic features of each group. We discuss how the biosphere transformed to its present state over the past four billion years. M. LaBarbera, A. Hunter, C. Andrews. Autumn. L.
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3.00 Credits
This course surveys the basic principles of ecology and evolutionary biology. Topics in evolutionary biology include the evidence for evolution, the history of life, the mechanisms of evolution (e.g., mutation, selection, genetic drift), adaptation, speciation, the origin of evolutionary novelties, the origin of life, and human evolution. Topics in ecology include demography and life histories, competition, predation, and the interspecific interactions that shape the structure of ecological communities. G. Dwyer, J. Coyne, C. Andrews. Winter. L.
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3.00 Credits
PQ: CHEM 10300, 11300, or 12300, or consent of instructor. The fundamental molecular processes of cells are examined using evidence from biochemical, physiologic, and microscopic analyses. Topics include the logical, spatial, and temporal organization and regulation of metabolism; the formation and function of proteins, RNA, and DNA; generation and function of cellular structures and compartments; regulation of gene expression; the organization and regulation of cell growth and division; and cell-environment and cell-cell interactions. L. Mets, B. Glick, C. Schonbaum. Autumn. L.
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3.00 Credits
PQ: BIOS 20191. The goal of this course is to integrate recent developments in molecular genetics and the human genome project into the structure of classical genetics. Topics include Mendelian inheritance, linkage, tetrad analysis, DNA polymorphisms, human genome, chromosome aberrations and their molecular analysis, bacterial and virus genetics, regulatory mechanisms, DNA cloning, mechanisms of mutation and recombination, and transposable elements. I. Ruvinsky, W. Dobyns, N. Ellis, C. Schonbaum. Winter. L.
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3.00 Credits
PQ: BIOS 20191 and 20192. This course is concerned with fundamental physiological functions and their relation to structure. In multicellular organisms, the responsibilities for preservation of an appropriate cellular milieu, substrate intake and metabolite excretion, circulation of substrates and metabolites, locomotion, and integration of function are achieved by specializations of cells into organs. The biological principles of organ development, interaction, regulation, and coordination to mediate survival of the organism are examined using models from simple multicellular organisms to humans. D. McGehee, D. Hanck, C. Andrews. Spring. L.
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3.00 Credits
PQ: First three quarters of either BIOS 20180s or 20190s. This course covers both the classical experiments that contributed to our understanding of developmental biology and the recent explosion of information about development made possible by a combination of genetic and molecular approaches. Examples from both vertebrate and invertebrate systems are used to illustrate underlying principles of animal development. A. Imamoto, R. Ho, C. Schonbaum. Spring. L.
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3.00 Credits
PQ: BIOS 20181-20182 or 20191-20192, and CHEM 22000-22100/23100. This course meets the biochemistry requirement in the biological sciences major. This course examines the chemical nature of cellular components, enzymes, and mechanisms of enzyme activity, energy interconversions, and biosynthetic reactions. Strong emphasis is given to control and regulation of metabolism through macromolecular interactions. M. Makinen, P. Strieleman, Autumn, Spring. L.; P. Strieleman, Summer. L.
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