EBME 417 - Excitable Cells: Molecular Mechanisms

Institution:

Case Western Reserve University

Subject:

Description:

Ion channels are the molecular basis of membrane excitability in all cell types, including neural, heart, and muscle cells. This course presents the structure and the mechanism of function of ion channels at the molecular level. It introduces the basic principles and methods in the ion channel study including the ionic basis of membrane excitability, thermodynamic and kinetic analysis of channel function, voltage clamp and patch clamp techniques, and molecular and structural biology approaches. The course will cover structure of various potassium, calcium, sodium, and chloride channels and their physiological function in neural, cardiac, and muscle cells. Exemplary channels that have been best studied will be discussed to illustrate the current understanding of the molecular mechanisms of channel gating and permeation. Graduate students will present exemplary papers in the journal club style. Recommended preparation: EBME 201 or equivalent. Offered as EBME 317 and EBME 417. Prereq: Graduate standing or Undergraduate with Junior or Senior standing and a cumulative GPA of 3.2 or above.

Credits:

3.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.case.edu

Phone Number:

(216) 368-2000

Regional Accreditation:

North Central Association of Colleges and Schools

Calendar System:

Semester

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