MIM U667 - Solid Mechanics of Cells and Tissues

Institution:

Northeastern University

Subject:

Description:

Focuses on the multiscale mechanical behavior of biological tissues. The mechanical integrity of a single cell depends on the mechanical properties and geometrical arrangements of the fiber network in the extracellular matrix. Introduces the statistical concept of persistent length and entanglement of long-chain polymer molecules, linear elasticity and viscoelasticity, membrane undulations, stability of vesicles. Discusses the intersurface forces that cause cells to adhere and to form microscopic, mesoscopic, and macroscopic two-dimensional membranes and three-dimensional structures. Introduces experimental techniques and measurements involving atomic force microscope, surface force apparatus, optical tweezers, micropipette aspiration. Provides examples for specific physiological and path-physiological phenomena related to mechanical and adhesion behavior of cells and membranes.

Credits:

4.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.northeastern.edu

Phone Number:

(617) 373-2000

Regional Accreditation:

New England Association of Schools and Colleges

Calendar System:

Semester

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