PHRM 630 - Frontiers in Bioorganic and Medicinal Chemistry

Institution:

University of Pennsylvania

Subject:

Description:

Dr. Ian Blair, Dr. Barry Cooperman, Dr. Dewey McCafferty. Prerequisite(s): Permission of the courses directors. This advanced course for graduate students will be based primarily on didactic lectures from three Penn faculty. Permission for a student to participate should first be obtained from one of the participating faculty. A solid background in chemistry and biochemistry will be required. Overviews of current and emerging topics in bioorganic and medicinal chemistry will be presented. Students will be given short "take home" problem sets, two formal interim examinations, and a formal final examination during the semester. Topics that will be covered over the semester include: Mass spectrometry of DNA and DNA-adducts, Synthetic peptides/peptide mimics/proteins, including the expansion of the genetic code; methods of synthesis and applications, Synthetic RNAs, DNAs and nucleic acid mimics: methods of synthesis and applications, Synthetic oligosaccharides: methods of sythesis and applications, Combinatorial chemistry, Enzymology of translation, Antibiotic biosynthesis, Introduction to drug metabolism, Characterization of drug metabolites, Characterization of reactive metabolites from drugs and endogenous molecules, DNA-adducts from drugs and endogenous molecules, Lipidomics in drug development.

Credits:

3.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.upenn.edu

Phone Number:

(215) 898-5000

Regional Accreditation:

Middle States Association of Colleges and Schools

Calendar System:

Semester

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