CAMB 638 - Advanced Seminar in Cell Death and Survival

Institution:

University of Pennsylvania

Subject:

Description:

X. Yang, W. El-Deiry, B. Keith. Prerequisite(s): BIOM 600. Instructor permit needed for anyone who has not taken BIOM600. The objective of this seminar course is to familiarize students with the pathways of cell death and cell survival in mammalian species as well as other organisms. The course has a strong emphasis on cancer and clinical applications of basic signaling. Specific areas that are covered include 1) the history of apoptosis research leading to the Nobel Prize in Medicine in 2002, 2) the structure, biochemical modifications and interactions that regulate death signaling in the cell intrinsic and extrinsic pathways, and 3) in vivo models that demonstrate physiological relevance. Additional emphasis is placed on understanding cell survival pathways including negative regulators of cell death and cross-talk with tumor suppressor and oncogene survival pathways. An effort is made each semester to include emerging topics including autophagy, ER stress signaling pathways, and the impact of micro-RNAs, as well as the tumor microenvironment on cell survival and cancer. There is a strong interest in therapeutic applications and future directions that are always part of the discussions and later in the course become the main focus. Students are expected to read and to participate in the discussion of all assigned papers, and students are responsible for presenting the papers and leading discussions on a rotating basis. In addition students prepare a News & Views type of report on an additional topic of interest.

Credits:

3.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.upenn.edu

Phone Number:

(215) 898-5000

Regional Accreditation:

Middle States Association of Colleges and Schools

Calendar System:

Semester

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