CAMB 650 - DNA Damage Checkpoints and DNA Repair

Institution:

University of Pennsylvania

Subject:

Description:

E. Brown, C. Bassing, and R. Greenberg. Prerequisite(s): Previous completion of CAMB 530 or equivalent introduction to cell cycle and DNA damage response regulation is recommended. Priority will be given to students in the Cell and Molecular Biology Graduate Group, followed by other Biomedical Graduate Studies graduate groups. If class fills, priority must be given to Cancer Biology Students. DNA damage checkpoint and repair genes are important suppressors of cancer and aging. These processes function as part of a complex interconnected network of DNA recognition and processing, checkpoint signaling cascades and DNA repair. Because these processes preserve genome integrity, how they cooperate with one another is directly related to their ability to suppress cancer and aging. To study this emerging research area, students in CAMB 650 critically evaluate key research findings published in the last five years. In addition to providing an advanced understanding of DNA damage checkpoints, DNA repair and the connections of these processes with cancer and aging, this course is designed to allow students to gain experience in critiquing scientific literature both independently and through group discussion. Take home questionnaire assignments and participation in class discussions willmake up 50% and 30% of each student's final grade, respectively. In the final two weeks of the course, each student will study and propose a future research topic in field of DNA damage responses, cancer and aging. Students will be expected to pose a question and propose how the question will be experimentally answered. In the final week of the course, each student will turn in a one page summary of this proposal and will present their proposal to fellow students for discussion and critique. The one page proposal, presentation and critique will comprise 20% each student's final grade.

Credits:

3.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.upenn.edu

Phone Number:

(215) 898-5000

Regional Accreditation:

Middle States Association of Colleges and Schools

Calendar System:

Semester

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