CAMB 632 - Cell Control by Signal Transduction Pathways

Institution:

University of Pennsylvania

Subject:

Description:

X. Hua, J. Field. Prerequisite(s): BIOM 600, cell biology, or other course focusing on cell and molecular biology. Priority given to CAMB graduate students. Open to non-CAMB graduate students who have taken BIOM 600 or other related course. Not open to non-graduate students. This course, "Cell control by signal transduction pathways", will examine how various signal transduction mechanisms influence cell functions including replication, growth, transcription, translation and intracellular trafficking. The primary signal transduction pathways to be examined include those mediate by Notch, TGF-_, TNF-a, Ras, and Rho. We will also discuss intracellular signaling in response to DNA damage and explore in depth some of the key classes of enzymes involved in transmitting sifnals including kinases and phosphatases. In the first half of the course, invited faculty members will pick 2 relatively recent papers from their field that aren't necessarily definitive, but are interesting and could lead to new potential questions/areas for future investigation. Each paper will be assigned to a student, who will meet with the faculty mentor prior to the class to discuss the paper and their presentation. During the class, students will present each paper for approximately 45 minutes with time for discussion. Students will present the important background, break down the paper, look for strengths and weakness and come up with a plan of what the next set of experiments could or should be. In the second half of the course, students will independently pick a signal transduction paper for in-class presentation and will also write a short "News and Views" style article based on the paper they have chosen. The goal is that the course will lead students to think more about experimental design and interpretation rather than re-iteration of the biology they have learned as undergraduates.

Credits:

3.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.upenn.edu

Phone Number:

(215) 898-5000

Regional Accreditation:

Middle States Association of Colleges and Schools

Calendar System:

Semester

The Course Profile information is provided and updated by third parties including the respective institutions. While the institutions are able to update their information at any time, the information is not independently validated, and no party associated with this website can accept responsibility for its accuracy.