CAMB 615 - Protein Conformation Diseases

Institution:

University of Pennsylvania

Subject:

Description:

Yair Argon;Harry Ischiropoulos. Prerequisite(s): BIOM 600 or equivalent. Protein misfolding and aggregation have been associated with a number of human diseases, ranging from Alzhemier's and Parkinson's Disease to Respiratory Distress Syndrome, alpha(1)-antitrypsin deficiency and Mad Cow Disease. This course will cover the common principles underlying such diverse diseases. The course will consist of lectures, directed readings, and student presentations and will cover seminal and current papers on the cell biology of conformational diseases. Examples of topics are cellular inclusion bodies, protein degradation pathways (proteosome vs. ER-associated degradation), effects of protein aggregation on cell function and mutations which lead to autosomal dominant diseases. Target audience is primarily 1st year CAMB students or other students interested in acquiring a cell biological perspective on the topic. MD/PhDs and Postdods are welcome.

Credits:

3.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.upenn.edu

Phone Number:

(215) 898-5000

Regional Accreditation:

Middle States Association of Colleges and Schools

Calendar System:

Semester

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