CAMB 530 - The cell cycle and cancer

Institution:

University of Pennsylvania

Subject:

Description:

Diehl, Alan; McMahon, S; Assoian, R. Prerequisite(s): Prerequisite of CAMB 512 and/or BIOM 600 or equivalent graduate level advanced cell biology course. Anyone without BIOM600 or equivalent must obtain instructor permission. This seminar course will focus on molecular and biochemical events that regulate cell cycle transitions and their relevance to human cancer. Topics will include control of the G1/S, G2/M transitions and S-phase initiation/progression. Participants will gain an understanding of the specific roles played by cyclins, cdks, and their inhibitors. The regulation of the cell cycle by tumor suppressor genes such as p16, Rb and p53, and by oncogenes such as cyclin D, cdc25A, MDM2, and c-myc, will also be explored. Where appropriate, the focus will be on understanding regulation of cell cycle control through transcriptional control of gene expression, protein-protein interactions, posttranslational modifications, (eg. phosphorylation), or regulation of protein stability, (eg. via ubiquitin-targeted degradation). Although achieving an improved understanding of mammalian cancer is a goal of the course, much of our knowledge of the cell cycle derives from work done in more genetically tractable organisms such as yeast, drosophila, and xenopus. Therefore a great deal of emphasis will be placed on studies performed in these model systems.

Credits:

3.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.upenn.edu

Phone Number:

(215) 898-5000

Regional Accreditation:

Middle States Association of Colleges and Schools

Calendar System:

Semester

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